Example sentences for: hfe
How can you use “hfe” in a sentence? Here are some example sentences to help you improve your vocabulary:
These observations imply that susceptibility alleles for CVID and IgGSD occur on haplotypes that sometimes include the HFE C282Y allele.
For the present analysis, all haplotypes were defined only by A and B alleles, and the ancestral haplotype was defined as a hemochromatosis-associated Ch6p bearing A*03-B*07 and HFE C282Y.
HFE mutation analysis and HLA typing of family members were performed to permit assignment of Ch6p haplotypes.
This disorder is typically associated with homozygosity for the C282Y mutation of the HFE gene (exon 2, nt 845 G→A) on Ch6p [ 1 ] . C282Y lies within an ancestral haplotype which includes the human leukocyte antigen (HLA) haplotype A*03-B*07 [ 2 3 4 5 ] . The ancestral haplotype is the predominant hemochromatosis-associated haplotype in many northwestern European countries, including Ireland [ 6 ] , Brittany [ 2 ] , Denmark [ 7 8 ] , Sweden [ 9 ] , and Germany [ 10 11 ] . This is attributed to the origin of the C282Y mutation on an A*03-B*07 haplotype in northwestern Europe and its early dissemination by Vikings [ 3 12 ] . Modification of the ancestral chromosome by recombination and admixture as a result of geographic migration explains the occurrence of chromosomes bearing C282Y in association with different HLA haplotypes [ 2 4 8 13 14 15 16 ] . Thus some non-ancestral haplotypes also occur with significantly increased frequencies in hemochromatosis patients in various countries in Europe and in descendants of Europeans [ 5 16 ] .
No patient declined to undergo HFE mutation analysis after it was determined that he/she had a hemochromatosis phenotype.
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