Example sentences for: hfe
How can you use “hfe” in a sentence? Here are some example sentences to help you improve your vocabulary:
In several countries in northwestern Europe, however, the percentage of C282Y homozygotes in hemochromatosis case series is greater than 90% [ 33 34 35 37 38 ] . In Queensland, a frequency of C282Y homozygosity of 100% was reported among patients identified by phenotype criteria [ 42 ] . Thus, the selection criterion of C282Y homozygosity in the present study nonetheless resulted in a group of hemochromatosis probands the HFE genotypes of which are similar to those of hemochromatosis patients of northwestern European descent in other studies.
HFE mutation analysis and HLA typing of family members were performed to permit assignment of Ch6p haplotypes.
A variety of HFE missense mutations occur in association with A*03-B*07 haplotypes in white Alabamians.
HFE mutation analysis was performed as previously described [ 23 ] . A and B alleles were detected using low-resolution DNA-based typing (PCR/sequence-specific oligonucleotide probe) in probands [ 23 ] . Control subjects were tested using the microdroplet lymphocytotoxicity test [ 25 ] ; subjects were evaluated using antisera that detected allele assignments described in the 9 thInternational Histocompatibility Workshop [ 26 ] . Because the levels of resolution of the DNA-based and serological typing methods we used are similar, alleles detected by these respective methods provide concordant allele assignments, with the exception of B*70 and B*71 that were not detected by serological methods.
For example, examination of the plots reveals that the hemochromatosis gene HFE, at 28 Mb on 6p, lies at the edge of a recombination 'cold spot' from 28-40 Mb.
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