Example sentences for: hfe
How can you use “hfe” in a sentence? Here are some example sentences to help you improve your vocabulary:
These observations imply that susceptibility alleles for CVID and IgGSD occur on haplotypes that sometimes include the HFE C282Y allele.
A variety of HFE missense mutations occur in association with A*03-B*07 haplotypes in white Alabamians.
2%) inherited the ancestral haplotype defined as A*03-B*07, HFE C282Y; 46 were heterozygous and 12 were homozygous for the haplotype.
Some of the haplotypes significantly associated with CVID and IgGSD in the present study also occur with significantly increased frequencies in central Alabama Caucasian hemochromatosis probands with homozygosity for HFE C282Y on Ch6p [ 10 ] . These haplotypes are A*03-B*07 and A*03-B*14 [ [ 10 ] ; present study].
HFE mutation analysis was performed as previously described [ 23 ] . A and B alleles were detected using low-resolution DNA-based typing (PCR/sequence-specific oligonucleotide probe) in probands [ 23 ] . Control subjects were tested using the microdroplet lymphocytotoxicity test [ 25 ] ; subjects were evaluated using antisera that detected allele assignments described in the 9 thInternational Histocompatibility Workshop [ 26 ] . Because the levels of resolution of the DNA-based and serological typing methods we used are similar, alleles detected by these respective methods provide concordant allele assignments, with the exception of B*70 and B*71 that were not detected by serological methods.