Example sentences for: hfe
How can you use “hfe” in a sentence? Here are some example sentences to help you improve your vocabulary:
Similarly, the frequency of A*03 positivity was significantly increased in Alabama hemochromatosis probands diagnosed before the discovery of HFE [ 21 ] . These observations are consistent with and extend the findings of 21 previously reported case-controlled studies from thirteen countries which demonstrate the significantly increased prevalence of A*03 in persons with hemochromatosis [ 16 ] . The alleles B*07 and B*14 were also more common in the present Alabama probands and in Alabama probands diagnosed before discovery of HFE than in corresponding control subjects [ 21 ] . The present analysis demonstrates that this is attributable largely to the association of B*07 and B*14 with A*03, consistent with observations in persons with hemochromatosis patients from many locations, including Ireland [ 6 ] , Brittany [ 2 32 33 34 ] , Denmark [ 7 8 ] , Sweden [ 9 35 36 ] , Germany [ 10 11 37 38 ] , Portugal [ 30 39 ] , Italy [ 2 40 ] , and Utah [ 20 ] .
2%) inherited the ancestral haplotype defined as A*03-B*07, HFE C282Y; 46 were heterozygous and 12 were homozygous for the haplotype.
For example, examination of the plots reveals that the hemochromatosis gene HFE, at 28 Mb on 6p, lies at the edge of a recombination 'cold spot' from 28-40 Mb.
Some of the haplotypes significantly associated with CVID and IgGSD in the present study also occur with significantly increased frequencies in central Alabama Caucasian hemochromatosis probands with homozygosity for HFE C282Y on Ch6p [ 10 ] . These haplotypes are A*03-B*07 and A*03-B*14 [ [ 10 ] ; present study].
Taken together, these observations could explain the occurrence of CVID or IgGSD and hemochromatosis due to HFE C282Y homozygosity in some of the present index patients [ 26 ] and account for the occurrence of IgA deficiency and hemochromatosis in different members of the same family [ 27 ] .
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