Words similar to hexokinase
Example sentences for: hexokinase
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In cultured human muscle cells, only the PI 3-kinase - p70 S6 kinase pathway, and not the MAPK pathway, mediates insulin up-regulation of p85α PI 3-kinase gene expression [ 26 ] . Similarly, in L6 myotubes, insulin induces hexokinase II gene transcription via the rapamycin-sensitive PI 3-kinase pathway, but not via the MAPK pathway [ 27 ] . The PI 3-kinase - p70 S6 kinase pathway, but not the MAPK pathway, mediates insulin induction of glucose-6-phosphate dehydrogenase gene expression in primary rat hepatocytes [ 28 ] . In H411E liver cells, insulin down-regulates cAMP-induced phosphoenolpyruvate carboxykinase gene transcription via the PI 3-kinase pathway, but not via the MAPK pathway [ 29 ] . Phosphorylated p70 S6 kinase has been shown to be present in the nucleus in insulin-treated cells [ 30 ] . Moreover, it has been shown that p70 S6 kinase phosphorylates and activates members of the cAMP response element modulator family of transcription factors [ 31 ] . These data raise the possibility that transcriptional regulation of SP-A gene expression occurs via the PI 3-kinase - p70 S6 kinase pathway.
This result suggests that phosphorylation by hexokinase may be required for inhibition of lipid breakdown.
Mannose is a glucose analog that has been postulated to affect seed germination [ 19 ] and sugar-regulated gene expression [ 31 32 ] via a signaling pathway that requires hexokinase activity.
Kinase reaction was terminated by depleting ATP with 1 μl of hexokinase (1 U/μl) and 2 μl of 10 × G+ I (1 μl 10 mg/ml PCL+ 20 μl 50% glucose + 79 μl H 2 O) for 20 min at room temperature.
This is consistent with hexokinase I being the predominant isoform in the embryonic heart [ 21].
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