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Example sentences for: hes

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It has been shown that the differentiation of pillar cells depends on activation of Fgfr3 [ 26 ] by FGF's, probably Fgf8, a factor produced by developing and mature inner hair cells [ 18 27 ] . The formation of supporting cells also appears to depend on the proper expression of various bHLH factors such as Hes 1 and 5 which appear to be regulated by the Notch signaling pathway [ 17 28 29 ] . It is possible that the apparent inability of fibers to extend along outer hair cells is related to the lack of differentiation of supporting cells in the absence of mature hair cells.
In GIST and HES, respectively, the analogous T670I mutation in KIT and T674I mutation in PDGFR-alpha have been associated with acquired resistance to this drug [15,16].
These results differ from those of acquired resistance mutation in CML [10], GIST [15,27], and HES [16].
Excess neurons also developed in mouse embryos homozygous for targeted mutation of HES1 , a presumptive downstream effector of Notch signaling [ 36].
Although imatinib inhibits different kinases in various diseases (BCR-ABL in CML, KIT or PDGFR-alpha in gastrointestinal stromal tumors [GISTs], and PDGFR-alpha in hypereosinophilic syndrome [HES]) (reviewed in [14]), some tumors that become refractory to treatment with imatinib appear to have analogous secondary mutations in the kinase-coding domain of the genes encoding these three enzymes.