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Example sentences for: hes

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These results differ from those of acquired resistance mutation in CML [10], GIST [15,27], and HES [16].
Excess neurons also developed in mouse embryos homozygous for targeted mutation of HES1 , a presumptive downstream effector of Notch signaling [ 36].
In GIST and HES, respectively, the analogous T670I mutation in KIT and T674I mutation in PDGFR-alpha have been associated with acquired resistance to this drug [15,16].
Although imatinib inhibits different kinases in various diseases (BCR-ABL in CML, KIT or PDGFR-alpha in gastrointestinal stromal tumors [GISTs], and PDGFR-alpha in hypereosinophilic syndrome [HES]) (reviewed in [14]), some tumors that become refractory to treatment with imatinib appear to have analogous secondary mutations in the kinase-coding domain of the genes encoding these three enzymes.
It has been shown that the differentiation of pillar cells depends on activation of Fgfr3 [ 26 ] by FGF's, probably Fgf8, a factor produced by developing and mature inner hair cells [ 18 27 ] . The formation of supporting cells also appears to depend on the proper expression of various bHLH factors such as Hes 1 and 5 which appear to be regulated by the Notch signaling pathway [ 17 28 29 ] . It is possible that the apparent inability of fibers to extend along outer hair cells is related to the lack of differentiation of supporting cells in the absence of mature hair cells.