Words similar to herpesviruses
Example sentences for: herpesviruses
How can you use “herpesviruses” in a sentence? Here are some example sentences to help you improve your vocabulary:
LH lymphotropic herpesviruses
Frequent infection with herpesviruses has long been recognized in patients undergoing allogeneic transplantation [ 7 8 ] and in patients with acute leukemia [ 1 2 ] . In patients with acute leukemia it has been reported that as many as two thirds of seropositive patients can develop reactivation of herpes simplex virus infection during remission induction therapy [ 26 ] . The risk of CMV infection in acute leukemia patients was recognized almost 30 years ago [ 27 ] but is of particular concern in patients undergoing allogeneic transplantation [ 2 28 ] . EBV infection is frequently associated with post-transplantation lymphoproliferative disorders in T cell-depleted grafts [ 29 ] . As recently reported, HHV-6 can also be associated with bone marrow supression [ 30 ] , encephalitis and pneumonitis [ 7 8 ] after allogeneic transplantation.
They usually produce inaparent infection or transient immune compromise in otherwise healthy hosts but are able to cause life-threatening primary or reactivated infections in individuals with congenital or acquired T-cell immunodeficiencies [ 7 8 9 10 11 12 13 14 15 ] . The spectrum of diseases caused by lymphotropic herpesviruses is well documented in patients undergoing bone marrow transplantation (BMT) [ 8 9 10 11 ] or organ transplantation [ 12 13 ] and in individuals infected with human immunodeficiency virus (HIV) [ 14 15 ] . In patients undergoing conventional anticancer therapy without BMT, the data focusing on EBV, CMV or HHV-6 infection are scarcely documented and mostly reported as individual cases [ 16 17 18 19 ] . With combined diagnostic approach of serology and viral DNA detection we performed a prospective study of children undergoing non-BMT therapy for cancer to demostrate the incidence of LH infections.
This approach had been pioneered in the classical work of Dobzhansky and Sturtevant who used inversions in Drosophila chromosomes to construct an evolutionary tree [ 12 ] . Subsequently, mathematical methods have been developed to calculate rearrangement distances between genomes, and, using these, phylogenetic trees have been built for certain small genomes, such as plant mitochondria and herpesviruses [ 13 14 ] . These approaches, however, are applicable only to genomes that show significant conservation of global gene order, which is manifestly not the case among prokaryotes [ 15 16 17 ] . Even relatively close species such as, for example, Escherichia coli and Haemophilus influenzae, two species of the γ-subdivision of Proteobacteria, retain very little conservation of gene order beyond the operon level (typically, two-to-four genes in a row), and essentially none is detectable among evolutionarily distant bacteria and archaea [ 15 16 18 ] . Very few operons, primarily those coding for physically interacting subunits of multiprotein complexes such as certain ribosomal proteins or RNA-polymerase subunits, are conserved across a wide range of prokaryotic lineages [ 15 16 ] . On the other hand, pairwise comparisons of even distantly related prokaryotic genomes reveal considerable number of shared (predicted) operons, which creates an opportunity for a meaningful comparative analysis [ 19 ] [ 20 21 ] .
To avoid this, CAP in micronized form (which does not aggregate at low pH), instead of CAP in soluble form is being considered as a topical microbicide [ 30 31 32 33 34 35 ] . Micronized CAP (Aquateric) was shown to be virucidal against HIV-1, herpesviruses and several nonviral sexually transmitted disease (STD) pathogens [ 30 31 32 33 34 ] . The virucidal activity of micronized CAP could at least partly be explained by its buffering capacity at low pH [ 40 ] since it is a free acid while other anionic polymeric microbicide candidates (except BufferGel, the active ingredient of which is Carbomer 974P [ 27 ] ) are sodium salts.
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