Words similar to herc
Example sentences for: herc
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To mark the regions of low-copy repeats in human 15q11-q13, we utilized a probe derived from the donor locus of a major component of the PWS/AS breakpoint duplication clusters, PAC clone pDJ-778A2 which contains a significant portion of the HERC2 gene in 15q13 [ 33 ] . In addition, we selected probes corresponding to sites distal to the PWS/AS domain flanking a large inverted-duplicated 15 (inv dup(15)) supernumerary marker chromosome [ 23 ] . Specifically, probe RPCI-11-88O16 (abbreviated RP11-88O16) was selected for FISH analysis because it lies distal to the inversion-duplication event breakpoint and is linked to STS marker D15S1010 [ 23 24 ] . Upon reaching the PTR inversion breakpoint interval with probe RP11-40J8, flanking BACs were chosen from the November 2002 human genome assembly to establish the extent of the interval and define the boundaries of the interval.
1 telomeric to HERC2 and BP3.
Another class of 15q duplicons has been termed LCR15s, for low copy repeats [ 18 19 ] . These share some sequences in common with the large HERC2 duplicons.
This suggests the possibility of such sequences upstream from APBA2 , most likely corresponding to BP3 or in a sequence gap between HERC2 and APBA2 . The existence of a duplicon-like region near APBA2 would most easily explain the duplication.
While public and private sequence assemblies now depict the correct location for this gene, previous published reports indicated that this gene mapped proximal to BP3 within the PWS/AS deletion and autism-associated interstitial duplication interval [ 21 22 ] . STS content mapping with regional clones confirms the predicted genomic assemblies and places this gene distal to the BP3 HERC2-containing breakpoint.
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