Words similar to heparin-binding
Example sentences for: heparin-binding
How can you use “heparin-binding” in a sentence? Here are some example sentences to help you improve your vocabulary:
To test whether the fibulin-1C interaction with proHB-EGF maps to the heparin-binding region, a construct, pGBT9/prodelHB-EGF, containing amino acid residues Asp 106-His 159(the entire EGF like region of proHB-EGF and 18 out of 32 residues of the heparin-binding region) [ 2 ] was used in the yeast two-hybrid system (see materials and methods).
The gene immediately centromeric to, and 12,840 bp from, SLC4A9 is HEGFL, which encodes a heparin-binding member of the EGF family.
Fibronectin contains three types of homology sequences, I-III; type I sequences bind heparin, Staphylococcus aureus, fibrin, and cell surfaces, type II sequences bind collagen and gelatin, and type III sequences bind DNA, cell surfaces, heparin, and fibulin-1 [ 40 43 ] . Fibulin-1 interacts with fibronectin through a heparin-binding region in type III 13 repeat; the binding of fibulin-1 to this site is independent of the binding of heparin as addition of exogenous heparin does not inhibit fibulin-1 binding to fibronectin [ 40 ] . The fibronectin-binding site in fibulin-1 is located in EGF-like modules 5 and 6 [ 44 ] ; the binding of fibulin-1 to fibronectin is a heterotypic interaction in which an EGF-like module binds to a non EGF-like domain (the type III 13 fibronectin repeat) [ 40 ] .
The interaction of fibulin-1C may map to the heparin-binding region of the extracellular domain of proHB-EGF or it may map to the EGF-like module of proHB-EGF or it may map to both of these regions within proHB-EGF.
These negatively-charged EGF-like modules of LTBP-3 may interact efficiently with the positively-charged heparin-binding domain of both the membrane-bound and soluble forms of HB-EGF.
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