Words similar to hepadnaviral
Example sentences for: hepadnaviral
How can you use “hepadnaviral” in a sentence? Here are some example sentences to help you improve your vocabulary:
Because hepadnaviral core particles are impermeable to large molecules, they were treated with low pH prior to the RNAseH assays to allow the substrate access to P within the cores [ 16].
The hepadnaviral RNAseH activity has not yet been directly measured in viral core particles, however, its existence is inferred from four observations, (i) Sequence alignment of P with known RNAseH enzymes reveals conserved motifs in P [ 17, 18, 19, 20].
Because genetic and biochemical analyses indicate that P possesses an intrinsic RNAseH activity, we conclude that the hepadnaviral RNAseH activity is likely to be "substrate committed" in a manner similar to the template commitment observed for its DNA polymerase activity.
The hepadnaviral DNA polymerase activity is strongly associated with the viral core structure and is normally unable to synthesize DNA from an exogenous template [ 16].
The hepadnaviral P protein possesses many unique features relative to the better studied reverse transcriptases of the retroviruses: (i) it uses its own amino-terminal domain as a protein primer for initiation of DNA synthesis [ 7, 9, 10], (ii) it cannot be isolated in an active form from virions without partial proteolysis or denaturation [ 13, 14, 15], and (iii) under normal circumstances it is active only on the endogenous pregenomic RNA that is encapsidated with it in the viral cores [ 16].