Words similar to hemochromatosis-associated
Example sentences for: hemochromatosis-associated
How can you use “hemochromatosis-associated” in a sentence? Here are some example sentences to help you improve your vocabulary:
For the present analysis, all haplotypes were defined only by A and B alleles, and the ancestral haplotype was defined as a hemochromatosis-associated Ch6p bearing A*03-B*07 and HFE C282Y.
Some previously reported hemochromatosis-associated HLA broad specificities are designated herein as corresponding splits (A*09 = A*23 and A*24; B*05 = B*51 and B*52; and B*12 = B*44 and B*45, respectively) [ 26 ] . A computer spreadsheet (Excel 2000, Microsoft Corp., Redmond, WA) and a statistical program (GB-Stat, v. 8.0 2000, Dynamic Microsystems, Inc., Silver Spring, MD) were used to perform the present analyses.
This disorder is typically associated with homozygosity for the C282Y mutation of the HFE gene (exon 2, nt 845 G→A) on Ch6p [ 1 ] . C282Y lies within an ancestral haplotype which includes the human leukocyte antigen (HLA) haplotype A*03-B*07 [ 2 3 4 5 ] . The ancestral haplotype is the predominant hemochromatosis-associated haplotype in many northwestern European countries, including Ireland [ 6 ] , Brittany [ 2 ] , Denmark [ 7 8 ] , Sweden [ 9 ] , and Germany [ 10 11 ] . This is attributed to the origin of the C282Y mutation on an A*03-B*07 haplotype in northwestern Europe and its early dissemination by Vikings [ 3 12 ] . Modification of the ancestral chromosome by recombination and admixture as a result of geographic migration explains the occurrence of chromosomes bearing C282Y in association with different HLA haplotypes [ 2 4 8 13 14 15 16 ] . Thus some non-ancestral haplotypes also occur with significantly increased frequencies in hemochromatosis patients in various countries in Europe and in descendants of Europeans [ 5 16 ] .
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