Example sentences for: hemochromatosis-associated

How can you use “hemochromatosis-associated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Some previously reported hemochromatosis-associated HLA broad specificities are designated herein as corresponding splits (A*09 = A*23 and A*24; B*05 = B*51 and B*52; and B*12 = B*44 and B*45, respectively) [ 26 ] . A computer spreadsheet (Excel 2000, Microsoft Corp., Redmond, WA) and a statistical program (GB-Stat, v. 8.0 2000, Dynamic Microsystems, Inc., Silver Spring, MD) were used to perform the present analyses.

  • This disorder is typically associated with homozygosity for the C282Y mutation of the HFE gene (exon 2, nt 845 G→A) on Ch6p [ 1 ] . C282Y lies within an ancestral haplotype which includes the human leukocyte antigen (HLA) haplotype A*03-B*07 [ 2 3 4 5 ] . The ancestral haplotype is the predominant hemochromatosis-associated haplotype in many northwestern European countries, including Ireland [ 6 ] , Brittany [ 2 ] , Denmark [ 7 8 ] , Sweden [ 9 ] , and Germany [ 10 11 ] . This is attributed to the origin of the C282Y mutation on an A*03-B*07 haplotype in northwestern Europe and its early dissemination by Vikings [ 3 12 ] . Modification of the ancestral chromosome by recombination and admixture as a result of geographic migration explains the occurrence of chromosomes bearing C282Y in association with different HLA haplotypes [ 2 4 8 13 14 15 16 ] . Thus some non-ancestral haplotypes also occur with significantly increased frequencies in hemochromatosis patients in various countries in Europe and in descendants of Europeans [ 5 16 ] .

  • For the present analysis, all haplotypes were defined only by A and B alleles, and the ancestral haplotype was defined as a hemochromatosis-associated Ch6p bearing A*03-B*07 and HFE C282Y.


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