Example sentences for: hemochromatosis

How can you use “hemochromatosis” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Probands were included who had: a) diagnosis of hemochromatosis in routine medical care during the interval 1997 - 2001; b) C282Y homozygosity; c) available HLA-A and -B typing; and d) residence in central Alabama.

  • Taken together, these observations could explain the occurrence of CVID or IgGSD and hemochromatosis due to HFE C282Y homozygosity in some of the present index patients [ 26 ] and account for the occurrence of IgA deficiency and hemochromatosis in different members of the same family [ 27 ] .

  • Nonetheless, the percentage of the present probands who were HLA-haploidentical with at least one other proband indicates that the haplotypes among hemochromatosis patients in central Alabama are more restricted than those in the general population [ 46 47 ] .

  • This disorder is typically associated with homozygosity for the C282Y mutation of the HFE gene (exon 2, nt 845 G→A) on Ch6p [ 1 ] . C282Y lies within an ancestral haplotype which includes the human leukocyte antigen (HLA) haplotype A*03-B*07 [ 2 3 4 5 ] . The ancestral haplotype is the predominant hemochromatosis-associated haplotype in many northwestern European countries, including Ireland [ 6 ] , Brittany [ 2 ] , Denmark [ 7 8 ] , Sweden [ 9 ] , and Germany [ 10 11 ] . This is attributed to the origin of the C282Y mutation on an A*03-B*07 haplotype in northwestern Europe and its early dissemination by Vikings [ 3 12 ] . Modification of the ancestral chromosome by recombination and admixture as a result of geographic migration explains the occurrence of chromosomes bearing C282Y in association with different HLA haplotypes [ 2 4 8 13 14 15 16 ] . Thus some non-ancestral haplotypes also occur with significantly increased frequencies in hemochromatosis patients in various countries in Europe and in descendants of Europeans [ 5 16 ] .

  • A presumptive diagnosis of hemochromatosis was established using an elevated transferrin saturation criterion; each proband was subsequently evaluated for iron overload and its complications [ 21 22 23 ] . All probands in the present study were white adults (> 18 years of age).


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