Words similar to hemochromatosis
Example sentences for: hemochromatosis
How can you use “hemochromatosis” in a sentence? Here are some example sentences to help you improve your vocabulary:
Similarly, the frequency of A*03 positivity was significantly increased in Alabama hemochromatosis probands diagnosed before the discovery of HFE [ 21 ] . These observations are consistent with and extend the findings of 21 previously reported case-controlled studies from thirteen countries which demonstrate the significantly increased prevalence of A*03 in persons with hemochromatosis [ 16 ] . The alleles B*07 and B*14 were also more common in the present Alabama probands and in Alabama probands diagnosed before discovery of HFE than in corresponding control subjects [ 21 ] . The present analysis demonstrates that this is attributable largely to the association of B*07 and B*14 with A*03, consistent with observations in persons with hemochromatosis patients from many locations, including Ireland [ 6 ] , Brittany [ 2 32 33 34 ] , Denmark [ 7 8 ] , Sweden [ 9 35 36 ] , Germany [ 10 11 37 38 ] , Portugal [ 30 39 ] , Italy [ 2 40 ] , and Utah [ 20 ] .
We compared the present results with data in a previously published tabulation of A and B haplotypes which occurred with significantly greater frequency in hemochromatosis patients than in corresponding control patients; data were available from Germany, Denmark, Sweden, Brittany, Portugal, Italy, Australia, and Utah (Table 5) [ Additional file 3] [ 16 ] [ 31 ] . Frequencies of the A*03-B*07 haplotype were increased in all hemochromatosis patient groups.
Nonetheless, the percentage of the present probands who were HLA-haploidentical with at least one other proband indicates that the haplotypes among hemochromatosis patients in central Alabama are more restricted than those in the general population [ 46 47 ] .
Based on clinical experience with hereditary hemochromatosis, the optimal range for HIC in patients with thalassemia major is considered to be between 3.2 and 7.0 mg/g dry weight, above which patients run an increased risk of complications, including hepatic fibrosis, diabetes mellitus, and - at concentrations above 15 mg/g - of cardiac disease and early death [ 2 ] . At the end of the respective observation periods, 67.
The frequency of the ancestral haplotype defined by A*03-B*07 in the present Alabama probands is greater than that reported in persons with hemochromatosis reported from most other areas.
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