Words similar to heme
Example sentences for: heme
How can you use “heme” in a sentence? Here are some example sentences to help you improve your vocabulary:
Though SGC α-subunits lack the histidine, the region encompassing the HNOB domain in human SGC1α has been shown to be important for functional heme binding by the dimeric enzyme [ 28 ] . Hence, in addition to covalent heme binding, HNOB domains may also interact with it non-covalently.
The latter may either cooperate in binding heme or might bind distinct ligands.
The transcription factors Ecm22p and Upc2p have been shown to induce the expression of ergosterol biosynthesis genes in response to low intracellular concentrations of ergosterol, whereas Hap1p is known to regulate the expression of these genes according to the availability of heme and oxygen, which are required for the pathway [ 43 44 ] .
A variety of environmental small molecules, namely, nutrients, xenobiotics and first messengers are recognized by cells, with the help of specialized protein sensors on their surfaces [ 1 2 ] . Additionally cells also use protein-bound small molecules, such as FAD, cinnamic acid, tetrapyrroles and heme as sensors of photons and the ambient redox states [ 3 4 ] . Within cells, small molecules, such as cyclic nucleotides, are used as intracellular messengers to transduce signals arising from a variety of stimuli [ 1 2 ] . Over the past few years a combination of protein sequence analysis and biochemical studies have revealed several unifying principles that govern the recognition of small molecules by cells [ 4 5 6 7 8 9 ] . A significant component of small molecule-protein interactions is mediated via a relatively small set of ancient conserved protein domains that bind their ligands using specialized pockets [ 4 10 ] . Certain protein folds have given rise to several large superfamilies of ligand-binding domains.
Majority of the bacterial HNOB domain proteins are predicted to covalently bind heme.
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