Example sentences for: heme

How can you use “heme” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Those versions that lack the heme-binding histidine might either non-covalently interact with heme, as in the case of the SGC α-subunits, or bind some other unknown ligand.

  • Likewise, the sE supplementation used caused low expression of the stress-induced isoform of heme oxygenase, (HO-1).

  • Alternatively, IDO might influence COX activity and expression through competition for or release of heme, which both enzymes require.

  • A variety of environmental small molecules, namely, nutrients, xenobiotics and first messengers are recognized by cells, with the help of specialized protein sensors on their surfaces [ 1 2 ] . Additionally cells also use protein-bound small molecules, such as FAD, cinnamic acid, tetrapyrroles and heme as sensors of photons and the ambient redox states [ 3 4 ] . Within cells, small molecules, such as cyclic nucleotides, are used as intracellular messengers to transduce signals arising from a variety of stimuli [ 1 2 ] . Over the past few years a combination of protein sequence analysis and biochemical studies have revealed several unifying principles that govern the recognition of small molecules by cells [ 4 5 6 7 8 9 ] . A significant component of small molecule-protein interactions is mediated via a relatively small set of ancient conserved protein domains that bind their ligands using specialized pockets [ 4 10 ] . Certain protein folds have given rise to several large superfamilies of ligand-binding domains.

  • HO-1 catalyzes the breakdown of prooxidant heme to biliverdin with release of carbon monoxide and iron ion.


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