Words similar to hcdr

Example sentences for: hcdr

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Thus, in the setting of specific B-cell clonal expansion without concomitant cellular activation, the DNA-based fingerprinting assay will indicate a dominant HCDR3 length, whereas the cDNA-based assay may not (data not shown).
These individual HCDR3 lengths are signatures of the various individual B-cell clones contained within the polyclonal population.
The immunoglobulin V H gene fingerprinting approach [ 23] takes advantage of the wide range of HCDR3 lengths that can occur in human B cells (approximately 5-35 amino acids) to provide an estimate of clonal diversity in polyclonal populations.
Conversely, in the setting of specific B-cell clonal activation without concomitant clonal expansion, the cDNA-based assay will indicate a dominant HCDR3 length, whereas the DNA-based assay may not.
Note that when cDNA prepared from normal peripheral blood B cells is used as a template for these V H family-specific and C H -specific assays, ladders of HCDR3 lengths that differ by three nucleotides are identified.