Words similar to hcdr

Example sentences for: hcdr

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This indicates that there are no dominant HCDR3 lengths that skew the Gaussian distribution, and therefore that there are no significant clonal expansions among the B cells that express most of these V H -C H combinations.
It should be pointed out that when an individual HCDR3 length comprises more than 50% of the radioactive counts of a V H -C H ladder, clonality, based on DNA sequencing, is very likely; when an individual length comprises more than 70% of the radioactivity, clonality is virtually assured (data not shown).
DNA sequence analyses of one of these two clones confirmed their identity, because each displayed the same rearranged V H DJ H gene with identical V H mutations and identical HCDR3 sequences (data not shown).
Note that when cDNA prepared from normal peripheral blood B cells is used as a template for these V H family-specific and C H -specific assays, ladders of HCDR3 lengths that differ by three nucleotides are identified.
During normal B cell development, the processes of gene segment recombination and coding end processing yield nucleotide HCDR3 lengths that are characteristic and virtually invariant for an individual B-cell clone.