Example sentences for: hcdr

How can you use “hcdr” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The immunoglobulin V H gene fingerprinting approach [ 23] takes advantage of the wide range of HCDR3 lengths that can occur in human B cells (approximately 5-35 amino acids) to provide an estimate of clonal diversity in polyclonal populations.

  • These individual HCDR3 lengths are signatures of the various individual B-cell clones contained within the polyclonal population.

  • Thus, in the setting of specific B-cell clonal expansion without concomitant cellular activation, the DNA-based fingerprinting assay will indicate a dominant HCDR3 length, whereas the cDNA-based assay may not (data not shown).

  • Finally, in the setting of specific B-cell clonal activation with concomitant clonal expansion, both the cDNA- and the DNA-based assays will indicate a dominant HCDR3 length.

  • DNA sequence analyses of one of these two clones confirmed their identity, because each displayed the same rearranged V H DJ H gene with identical V H mutations and identical HCDR3 sequences (data not shown).


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