Words similar to hcdr

Example sentences for: hcdr

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This indicates that there are no dominant HCDR3 lengths that skew the Gaussian distribution, and therefore that there are no significant clonal expansions among the B cells that express most of these V H -C H combinations.
Finally, in the setting of specific B-cell clonal activation with concomitant clonal expansion, both the cDNA- and the DNA-based assays will indicate a dominant HCDR3 length.
When polyclonal B lymphocytes from adults are analyzed using this assay, they display a Gaussian HCDR3 length distribution around a mean of approximately 15 amino acids.
Note that when cDNA prepared from normal peripheral blood B cells is used as a template for these V H family-specific and C H -specific assays, ladders of HCDR3 lengths that differ by three nucleotides are identified.
The immunoglobulin V H gene fingerprinting approach [ 23] takes advantage of the wide range of HCDR3 lengths that can occur in human B cells (approximately 5-35 amino acids) to provide an estimate of clonal diversity in polyclonal populations.