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Example sentences for: hcc

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Chromosomal regions that contained a gene-expression bias with at least 95% confidence (a sign test z -statistic of at least 1.96, see Materials and methods) were identified for all 104 HCC expression profiles (Figure 1b).
In the small region of chromosome 8q presented in Table 1, two other genes (for squalene monooxygenase and pro2000) do show increased expression in a majority of HCC samples.
To determine if CGMA predictions were consistent with other cytogenetic profiling studies, the CGMA data were compared with data from two of the largest CGH profiling studies (67 and 50 samples, respectively) using HCC tumors [ 11, 12].
As CGMA analysis yields more intuitive predictions if the tumor expression data is compared to a normal tissue reference, the original HCC gene-expression data was mathematically transformed such that the pooled cell-line reference was replaced by a normal tissue reference ([ 3], see Materials and methods).
CIS, carcinoma in situ ; HCC, hepatocellular carcinoma; IGF2, insulin-like growth factor 2; LOH, loss of heterozygosity; M6P/IGF2R, mannose 6-phosphate/insulin-like growth factor 2 receptor; PCR, polymerase chain reaction; SNP, single nucleotide polymorphism; TGFβ, transforming growth factor beta; UTR, untranslated region.