Words similar to hb-egf
Example sentences for: hb-egf
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The trafficking of such growth factors as HB-EGF and TGF-β and structural proteins within the extracellular matrix is important in wound healing processes.
The membrane-bound precursor and soluble forms of heparin-binding epidermal growth factor-like growth factor (HB-EGF) contribute to a variety of cellular developmental processes [ 1 ] . The observations of HB-EGF in cell and tissue types have suggested roles for HB-EGF in numerous cellular and tissue events such as: cell movement, extracellular matrix formation, tumor formation and cell adherence [ 1 ] . As described above, the membrane-bound precursor of HB-EGF (proHB-EGF) is also the cell-surface receptor for diphtheria toxin (DT) in DT-sensitive cells [ 2 ] .
These negatively-charged EGF-like modules of LTBP-3 may interact efficiently with the positively-charged heparin-binding domain of both the membrane-bound and soluble forms of HB-EGF.
These are reasonable functions for the role of the proposed mHB-EGF :LTBP-3 protein:protein interactions as the expression of both mHB-EGF and TGF-β is important during extracellular matrix formation in wound healing [ 1 25 ] ; it has been suggested that the coordinated activities of HB-EGF and TGF-β regulate the wound healing process [ 16 ] .
the interaction of fibulin-1C with aggrecan and versican) between extracellular matrix proteins argues for the interaction of the EGF-modules containing within fibulin-1C and LTBP-3 with either the heparin-binding region or with the EGF-like domain of HB-EGF.