Words similar to hb-egf
Example sentences for: hb-egf
How can you use “hb-egf” in a sentence? Here are some example sentences to help you improve your vocabulary:
Recently it has been reported that treatment of EGF-responsive, nontransformed rat intestinal crypt cell line RIE-1 cells with TGF-β resulted in an increased level of expression of HB-EGF [ 16 ] . LTBP-3 is a protein that is ubiquitous in tissues and cells.
The membrane-bound precursor and soluble forms of heparin-binding epidermal growth factor-like growth factor (HB-EGF) contribute to a variety of cellular developmental processes [ 1 ] . The observations of HB-EGF in cell and tissue types have suggested roles for HB-EGF in numerous cellular and tissue events such as: cell movement, extracellular matrix formation, tumor formation and cell adherence [ 1 ] . As described above, the membrane-bound precursor of HB-EGF (proHB-EGF) is also the cell-surface receptor for diphtheria toxin (DT) in DT-sensitive cells [ 2 ] .
The involvement of HB-EGF in various cellular and tissue functions and its presence in extracellular matrices suggested the possibility that it may interact with other extracellular matrix proteins.
Therefore, the interactions of HB-EGF with LTBP-3 and fibulin-1C described in this study suggest novel functions for HB-EGF between cell-surfaces and tissue surfaces.
The amino acid sequence of the heparin-binding region of HB-EGF ( 21KRKKKGKGLGKKRDPCLRKYK 41) [ 2 ] has been shown to have a strong affinity for heparin and may influence the interaction of this growth factor with cell-surface negatively charged heparan sulfate proteoglycans [ 22 ] . It remains to be seen whether specific/all of the EGF-like modules are required and whether calcium is needed for the interaction of HB-EGF with LTBP-3.
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