Words similar to hallmark
Example sentences for: hallmark
How can you use “hallmark” in a sentence? Here are some example sentences to help you improve your vocabulary:
One of the hallmarks of cancer includes the accumulation of mutations in key genes, namely DNA repair genes [ 4 ] , tumor suppressor genes [ 5 6 ] , and proto-oncogenes [ 5 6 ] , accompanied by the loss of the wildtype allele, resulting in loss of heterozygosity [LOH, see reviews by [ 7 8 9 ] ]. Pancreatic cancer, which results in the death of approximately 30,000 Americans annually and is the fourth leading cause of cancer mortalities in the United States, exhibits this hallmark [ 10 ] . For example, in pancreatic cancer there is a high incidence of mutations (>50%) in the tumor suppressor genes p16, p53 and DPC4 and approximately 90% of cases coincide with a mutation in the oncogene K- ras 2 [see review by [ 11 ] ]. Furthermore, a significant percentage of tumors harboring a mutated copy of DPC4 or p53 also lose the corresponding wildtype allele, resulting in LOH [see reviews by [ 11 12 ] ].
The morphological changes occurring in cells with accumulated Rab24(D123I) inclusions did not match the hallmark features of apoptosis ( e.g. , membrane blebbing, condensation of chromatin at the nuclear periphery).
In the pages of The Rules , men are a barely individualized collection of amiable dolts, but the Rules Girl is a particular social type--and it isn't the choosy free spirit lectured in such anti-feminist self-help books as Smart Women, Foolish Choices . The woman depicted as in need of the Rules is a voracious doormat, the sort of woman who sends men Hallmark greeting cards or long letters after a single date, who rummages in men's drawers and pockets, suggests couples therapy when brief relationships start to crumble, throws away a new boyfriend's old clothes, cleans (and redecorates) his apartment without asking, and refuses to see the most obvious signs of disengagement.
Specifically, we show for the first time that both AGE and FFA PA induce PTEC apoptosis through CD36-mediated activation of src kinase, p38 MAPK, and caspase 3. Because high glucose stimulates CD36 expression in human PTECs and because CD36 expression is increased in apoptotic tubular epithelial cells in human DNP, we propose a two-step metabolic hit model relevant for TED, a hallmark of progression of human DNP.
The tissue metrics % clear space and area % vacuoles were negatively correlated with at least one isoform of cytochrome P450 (3A9:U46118, 2B12:X63545 and 2B3:M20406), this may be a hallmark of recovery.
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