Words similar to guanylyl
Example sentences for: guanylyl
How can you use “guanylyl” in a sentence? Here are some example sentences to help you improve your vocabulary:
NO is released by a cell through the action of the nitric oxide synthase (NOS) on its substrate, the amino acid arginine [ 20 ] . NO diffuses through the neighboring cells and elicits its functions by activating a soluble guanylyl cyclase (SGC) that synthesizes cGMP using GTP as a substrate [ 16 18 ] . The animal SGCs are dimeric enzymes comprised of two homologous subunits, α and β.
The soluble guanylyl cyclases are important signaling molecules in animals that transduce signals mediated by the gaseous first messenger, nitric oxide [ 16 17 18 19 ] . In animals, NO functions as a neurotransmitter both in the central and peripheral nervous system.
Analogous active sites, that coordinate two metal ions, are observed in domains with similar activities, such as the classical adenylyl/guanylyl cyclases, family B DNA polymerases, pol-β fold nucleotidyl transferases, and triphosphatases or phosphoesterases of the HD and DHH superfamilies [ 11 15 19 20 ] . Consistent with these observations, both CyaB and ThTPase have been shown to require Mg 2+ions for their nucleotide cyclase and phosphatase activities [ 16 17 ] .
Thus, the HNOB and HNOBA domains resemble functionally similar CACHE and CHASE domains, which have also been acquired by certain eukaryotic lineages via lateral transfer from bacteria [ 14 36 37 ] . A phylogenetic analysis of the guanylyl cyclase domains of the animal SGCs shows that their closest relatives are cyclases from various bacteria such cyanobacteria, and Leptospira (data not shown).
Using sequence profile searches we identify two conserved domains in the N-terminal extensions of the soluble guanylyl cyclases from animals.
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