Words similar to guanylyl
Example sentences for: guanylyl
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At convergence, this search detected, in addition to the soluble guanylyl cyclases from the animals, several bacterial proteins, including certain methyl-accepting chemotaxis receptors from bacteria such as Desulfovibrio and Clostridium . Transitive searches initiated with the small bacterial proteins that entirely correspond to the N-terminal-most domain of the SGCs also recovered the same set of proteins as observed in the earlier search, with e <.01.
NO is released by a cell through the action of the nitric oxide synthase (NOS) on its substrate, the amino acid arginine [ 20 ] . NO diffuses through the neighboring cells and elicits its functions by activating a soluble guanylyl cyclase (SGC) that synthesizes cGMP using GTP as a substrate [ 16 18 ] . The animal SGCs are dimeric enzymes comprised of two homologous subunits, α and β.
Classic adenylyl and guanylyl cyclases show a far more sporadic distribution, and are often present in multiple copies fused to a variety of signaling domains such as the cyclic nucleotide binding domains [ 24 ] . Cyclic nucleotide generating activity is not known to exist in a subset of the archaea [ 25 ] , though most of them contain a well-conserved copy of the CYTH domain.
Thus, the HNOB and HNOBA domains resemble functionally similar CACHE and CHASE domains, which have also been acquired by certain eukaryotic lineages via lateral transfer from bacteria [ 14 36 37 ] . A phylogenetic analysis of the guanylyl cyclase domains of the animal SGCs shows that their closest relatives are cyclases from various bacteria such cyanobacteria, and Leptospira (data not shown).
The soluble guanylyl cyclases are important signaling molecules in animals that transduce signals mediated by the gaseous first messenger, nitric oxide [ 16 17 18 19 ] . In animals, NO functions as a neurotransmitter both in the central and peripheral nervous system.
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