Words similar to gt-rich

Example sentences for: gt-rich

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Subsequently, sequence analysis identified KRC as a member of the ZAS family of proteins which share the ability to bind κB-like motifs [ 15 ] . DNA competition analysis showed that KRC fusion proteins containing the ZAS-C domain bind specifically to both the RSS and to the κB motif [ 14 28 ] . DNA footprinting analysis further showed that KRC/ZAS-C binds to specific nucleotides within the κB and the heptamer of the RSS [ 14 ] . In this study, using a PCR-based DNA-binding site-selection and amplification procedure, we demonstrated that both the N-terminal ZAS-N and the C-terminal ZAS-C domains are able to bind GT-rich DNA sequences, and confirmed that the RSS and κB motifs are the high-affinity targets of KRC.
For example a copy of GGTTT and its complement can form a sequence GG(N 5-6 )CC, fulfilling the minimal DNA binding requirement for the ZAS proteins other than a lack of the 5' guanine [ 25 ] . Similarly, the GT-rich RSS nonamer and the palindromic RSS heptamer can serve as binding sites of KRC.