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Example sentences for: gshbs

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These motifs were present in different orders in the bacterial and eukaryotic GshBs (see Figure 8) because motif 5 is involved in the circular permutation that moves part of the carboxy-terminal domain to the amino-terminal domain of the eukaryotic enzymes.
The question of whether eukaryotic GshBs are members of the ATP-grasp superfamily is difficult to answer with certainty because the eukaryotic GshBs are so dramatically different from the other superfamily members.
We ran Shotgun with a query set containing six eukaryotic GshBs, eight bacterial GshBs, eight S6 modification enzymes (four from bacteria and four from archaea), and four proteins of unknown function (three from bacteria and one from the archaeon Methanococcus jannaschii ). Sample outputs are shown in Figure 7. Generally, sequences were found by either bacterial GshBs and the S6 modification enzymes, or by eukaryotic GshB proteins, but not by both groups.
This recruitment apparently took place independently in the bacterial and eukaryotic lineages, since the sequence of the eukaryotic GshB is remarkably different from that of the bacterial GshBs, despite the structural similarities between these two proteins.
GshBs have a different structural fold, characteristic of the ATP-grasp superfamily.