Example sentences for: grs

How can you use “grs” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Thus, in the absence of physiological concentrations of PP5, GRs accumulate in the nucleus of A549 cells.

  • Alternatively, the data is also consistent with PP5 acting to promote the nuclear export of the GRs.

  • Like other steroid hormone receptors, GRs are phosphoproteins, and reversible phosphorylation of specific ser/thr residues on the GR or associated proteins has been implicated in the regulation of 1) hormone binding to the cytoplasmic GR-complex, 2) the translocation of the GR between the cytoplasm and the nucleus, 3) the binding of ligand activated GR to consensus GRE in the promoter regions of GR-responsive genes, and 4) the formation of an active transcriptional complex [ 1, 2, 5, 6, 7, 8, 28, 29, 30, 31].

  • Still, it is not yet clear if PP5 acts to suppress the nuclear accumulation or to facilitate the nuclear export of GRs.

  • These studies indicate that PP5 mediated suppression of GR-function arises from the ability of PP5 to suppress the nuclear accumulation of GRs.


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