Words similar to gr
Example sentences for: gr
How can you use “gr” in a sentence? Here are some example sentences to help you improve your vocabulary:
Aside from its well-characterized role in protein folding [ 66 ] , Hsp70 is known to associate with the GR in the cytoplasm, where it promotes formation of a heterocomplex between the inactive GR and Hsp90 [ 67 ] . In addition, Hsp70 becomes concentrated in the nucleus when cells are exposed to environmental stress [ 68 ] . Of particular note, the nuclear accumulation of the Hsp70, Ssa4p, in response to nutrient deprivation in yeast appears to occur by a novel mechanism that involves its direct interaction with Mmd5p, a member of the importin-β family [ 69 ] . A role for Rab24 in nuclear trafficking would be unanticipated, since the only GTPase known to function in nuclear import/export (Ran) is structurally distinct from the Rab subgroup of the Ras superfamily [ 70 71 ] . Nevertheless, we can speculate that if Rab24 participates in a stress-induced pathway for nuclear import of Hsp70 in mammalian cells, the constitutive overexpression of Rab24(D123I) might stimulate aberrant accumulation of Hsp70/importin-β aggregates at the nuclear pore complex.
Increasing CORT/GR function in vivo is associated with a significant decline in TGF-β expression and a significant increase in cell division.
Therefore, PP5 appears to act as a suppressor of GR-induced gene expression via a mechanism that does not alter receptor number or the binding of hormone to the GR.
Recent studies with okadaic acid suggest phosphorylation alters the high affinity binding of GR to hsp-90, and that an intact cytoskeleton is required for ligand-activated GR translocation through the cytoplasm to the nucleus [ 8].
These studies revealed that the suppression of PP5 expression had no apparent effect on dexamethasone binding, suggesting that PP5 does not affect the formation of the high-affinity ligand binding complex or hormone binding to the GR [ 25].
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