Words similar to gr

Example sentences for: gr

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This finding is consistent with data obtained from gel-shift analysis and transfection studies conducted with GR-reporter plasmids, where a decrease in PP5 levels facilitates the association of GR with DNA and produces an increase in GR-transactivation [ 25].
Glucocorticoids (CORT) function through the GR to both activate specific gene expression as well as transrepress NF-κB [ 41 ] . Since GR confers this latter effect by associating through protein-protein interactions with NF-κB bound at κB response elements [ 43 44 45 46 47 ] , it is important to also evaluate changes in GR protein levels (see below).
Upon agonist binding, the complex undergoes a transformation, and the ligand bound GR translocates into to the nucleus in a manner that is determined by a nuclear localization sequence (NLS) contained in the receptor [ 4].
It is instructive that, of the 53 Connections Map transcripts with altered expression (Table 1), 4 genes of diverse pathways but overlapping function best discriminate control from SN50-treated explants: PCNA, GR, BMP1, BMP3b.
Therefore, the previously reported increase in GR-induced transcriptional activity that occurs after ISIS 15534 induced suppression of PP5 expression likely results from the nuclear accumulation of GR in a form that is capable of binding DNA yet still requires agonist to elicit maximal transcriptional activation.