Example sentences for: gqα

How can you use “gqα” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Moreover, our finding that GnRH-stimulated IP 3 production was inhibited supports the locus of the RGS3 effect as residing at phospholipase C or earlier in the transduction pathway, most likely at the Gα protein because of our studies both earlier [ 9 ] and here showing that RGS3 binds Gqα in vitro.

  • For instance, RGS4 and RGS-GAIP [ 11 ] , RGS3 [ 9 ] , RGS2 [ 46 ] , and RGS7 (our unpublished findings) all bind Gqα, the established G protein that transduces GnRH receptor signaling [ 38 ] . Nevertheless, RGS2 and 4 [ 9 ] , and RGS-GAIP and RGS7 (our unpublished data) are weak or null inhibitors of GnRH receptor signaling.

  • Significant (p < 0.05) amounts of Gi2α, Gi1α, Goα, and Gsα also were bound but were not as high as Gqα, Gzα, and Gi3α.

  • A recent report seems to have clarified this issue: RGS4 must bind not only Gqα but also selected Gq-coupled receptors before it can inhibit receptor signaling [ 47 48 ] . Based on this finding, we propose that RGS3's binding to the GnRH receptor as well as to Gqα accounts for its specific inhibiting of GnRH receptor signaling.

  • These results confirm our previous findings that RGS3 interacts with Gqα but also show that it has significant interaction with all other Gα-proteins studied.


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