Words similar to gqα
Example sentences for: gqα
How can you use “gqα” in a sentence? Here are some example sentences to help you improve your vocabulary:
Moreover, our finding that GnRH-stimulated IP 3 production was inhibited supports the locus of the RGS3 effect as residing at phospholipase C or earlier in the transduction pathway, most likely at the Gα protein because of our studies both earlier [ 9 ] and here showing that RGS3 binds Gqα in vitro.
For instance, RGS4 and RGS-GAIP [ 11 ] , RGS3 [ 9 ] , RGS2 [ 46 ] , and RGS7 (our unpublished findings) all bind Gqα, the established G protein that transduces GnRH receptor signaling [ 38 ] . Nevertheless, RGS2 and 4 [ 9 ] , and RGS-GAIP and RGS7 (our unpublished data) are weak or null inhibitors of GnRH receptor signaling.
Significant (p < 0.05) amounts of Gi2α, Gi1α, Goα, and Gsα also were bound but were not as high as Gqα, Gzα, and Gi3α.
A recent report seems to have clarified this issue: RGS4 must bind not only Gqα but also selected Gq-coupled receptors before it can inhibit receptor signaling [ 47 48 ] . Based on this finding, we propose that RGS3's binding to the GnRH receptor as well as to Gqα accounts for its specific inhibiting of GnRH receptor signaling.
These results confirm our previous findings that RGS3 interacts with Gqα but also show that it has significant interaction with all other Gα-proteins studied.
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