Words similar to glutamic
Example sentences for: glutamic
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GABA is a well-documented neurotrophic agent involved in brain development [ 27 28 29 30 ] . Most of the work done on the effects of GABA and neural development has been done on embryos and embryonic tissue well past the neural tube stage [ 27 31 32 ] . However, there is evidence of glutamic acid decarboxylase (GAD) and GABA receptor expression about the time of neural tube formation [ 27 ] . Given that GABA is important to neural development, and the early developmental time frame of the GABA system, it is logical that agents active at the GABA receptor (ethanol, BDZs) can have adverse consequences on CNS development.
T1DM susceptibility in the NOD mouse is linked to I-A g7, the murine MHC class II gene that encodes a histidine at position 56 and a serine at position 57 in the β chain, in place of the more frequent proline 56β and aspartic acid 57β [ 3 ] . The development of diabetes is prevented in NOD.PD mice (which are NOD mice with I-A g7) that carry a β chain transgene with site-specific mutations that restore proline and aspartic acid at positions 56β and 57β, respectively [ 4 ] . Furthermore, because of the two amino acid changes in the additional (transgenic) MHC class II allele β chain in NOD.PD mice, NOD.PD mice recognize three additional peptide epitopes in the glutamic acid decarboxylase 65 (GAD65) autoantigen [ 5 ] .
Among the few RGD mutants that have been isolated, on is RED, a low fitness mutant in which the glycine is replace by glutamic acid [ 53 ] . Ruíz-Jarabo and co-workers found that after revertant RGD genomes became dominant, and mutant genomes were no longer detected in the consensus sequence, RED was able to remain in the population for very long times and at surprisingly high frequencies [ 42 43 44 45 ] . There is a qualitative agreement between the predictions of the quasispecies model and this result, but there is also a quantitative discrepancy.
The phosphonate group of the NMDA antagonist binds to the glutamate-receptor, as does the natural agonist glutamic acid, but no conformational change that activates the NMDA channel occurs [ 28 ] . Beart et al [ 21 ] performed a SAR analysis of this type of NMDA antagonists.
All identified proteins have eight predicted membrane-spanning domains (TM1 - TM8) and share the completely conserved amino acid triplet C (cysteine) - W (tryptophan) - E (glutamic acid), predicted to be located in the extracellular loop upstream of TM6 (Figure 2).
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