Words similar to gjs

Example sentences for: gjs

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Less is known about the effects of carbenoxolone on GJs, although it has been proposed that glycyrrhetinic acid, to which carbenoxolone is related, binds directly to connexin molecules causing a conformational change leading to a closure of the junction [ 7 ] . Modeling studies indicate that neuronal synchronization can be mediated by low densities of GJs either between dendrites, as long as these dendrites are excitable [ 10 ] , or between the axons of pyramidal cells [ 11 ] . Furthermore, the electrotonic coupling could be promoted during epileptogenesis [ 12 13 ] .
Carbenoxolone, the succinyl ester of glycyrrhetinic acid [ 1 ] , is now used in clinical treatment of ulcer diseases [ 2 ] . It has some pharmacological properties such as: the inhibition of 11β-hydroxy steroid dehydrogenase (11β-HSD) [ 1 ] , and inhibition of gap junctional intercellular communication [ 3 ] . Electrotonic synaptic communication between neurons via gap junctions (GJs) is increasingly recognized as an important synchronizing mechanism in the brain.