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Example sentences for: gj

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In normal erythroid cells it acts as a repressor of the β-globin gene [ 22 23 ] . However, BP1 was also expressed in 47% of the adult and 81% of the pediatric acute myeloid leukemia patients we examined, and its overexpression increased the leukemogenic potential of K562 cells in vitro [ 11 ] . Molecular analysis revealed that BP1 expression is required for the survival of K562 leukemia cells, suggesting that BP1 might be part of an anti-apoptotic pathway (Davenport GJ, Fu S, Haga SB, Do K, Stevenson H, Pinzone J, Chase MB, Berg PE, unpublished data).
It is suggested that carbenoxolone, by blocking GJ channels inhibits both the induction and duration of epilepsy in the in vivo models of seizures.
As a matter of fact it was suggested that the gap junction coupling state between neurons in SCN is not static but dynamically regulated by the GABA A receptor system [ 14 ] . Also in vitro guinea-pig brain preparation prolonged seizure-like activity elicited using a brief application of bicuculline was abolished by the GJ channel blockers octanol and glycyrrhetinic acid as well as by intracellular acidification [ 16 ] .
gj
To begin to identify genes that might be targets of BP1, we have overexpressed BP1 in K562 cells and screened a microarray (Davenport GJ, Fu S, Haga SB, Do K, Stevenson H, Pinzone J, Chase MB, Berg PE, unpublished data).