Words similar to giantin
Example sentences for: giantin
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The identified autoantigens referred to are golgin-160/GCP170 [ 7 8 ] , golgin-95/gm130 [ 7 ] , golgin-97 [ 9 ] , golgin-245/ p230 [ 10 11 12 ] , giantin/macrogolgin/GCP372 [ 13 14 ] , and golgin-67 [ 15 ] . These proteins are characterized by predominant α-helical coiled-coil domains, except for N-termini and C-termini.
Recombinant golgin-160 (amino acids 787-1348, GenBank accession number BAA23661), giantin (amino acids 851-1496, GenBank accession number NP_004478), gm130 (amino acids 370-990, GenBank accession number AAF65550), and golgin-97 (amino acids 1-767, GenBank accession number AAB81549) proteins were purified by affinity nickel column chromatography.
A region of the GPC60 molecule that rather precisely encompasses the GOLD domain has been shown to bind to the cytoplasmic region of the Golgi membrane protein Giantin [ 16].
In contrast, native golgin-160 and giantin were degraded into their respective fragments 12 hours after the addition of STS.
Cleavage of golgin-160 and giantin may thus play a potentially important role in the early stages of apoptosis.