Words similar to genotoxic
Example sentences for: genotoxic
How can you use “genotoxic” in a sentence? Here are some example sentences to help you improve your vocabulary:
p38 MAPK is involved in p53 activation by genotoxic stress [ 46], and may be responsible for p53 phosphorylation at serine 33 in response to DNA damage.
Phyllanthus urinaria plant was used by Caribs with other plants in a bath against bad luck (called 'piai') [ 66 ] . Pharmacological activities of various compounds in some species of Phyllanthus include analgesic, antiinflammatory, antilipoxigenase, antiallergic, nitrosamina blocker, aldose reductase inhibitor, antiviral, mitochondrial ATPase inhibitor, phosphodiesterase inhibitor and cyclooxigenase inhibitor [ 111 ] . Other activities are hepatoprotective, phosphorilase and tirosine kinase inhibitor, phospholipase A 2 inhibitor and increased the survival of hepatocellular carcinoma harbouring animals [ 54 111 113 112 ] . The compound with hepatoprotective activity is triacontanol [ 114 ] . Several compounds found in Phyllanthus species, like flavonoids (quercetin, rutin), tannins (geraniin, furosin), benzenoids (ethyl gallate, methyl gallate) and phytosterols showed antinociceptive effects in mice or multiple mechanisms of action [ 111 115 ] . The flavonoids also have anti-inflammatory properties [ 38 11 ] . The hydroalcoholic extracts of four Phyllanthus species were 2 - 6 fold more active in causing antinociception than aspirin depending on the route of administration and the pain model used [ 115 ] . Phyllanthus amarus has antioxidant properties, reverses chromosomal alterations induced by genotoxic agents and has anticancer activity [ 112 ] . Active compounds may be flavonoids (quercetin, astragalin), ellagitannins (amarinic acid), hydrolysable tannins (phyllanthisiin D) [ 112 ] . The multiple plant compounds found in Phyllanthus species might help clear up any physiological condition that results in dogs having difficulty following game animals.
Doxorubicin (DOX) is a cytotoxic drug with prooxidant properties known to cause genotoxic damage resulting in an increase in number of erythrocytes with a micronucleus.
Other PIKK family members also function to orchestrate eukaryotic genotoxic stress responses, including human ATM, ATR, and DNA-dependent protein kinase (DNA-PKcs), TEL1 and MEC1 of Saccharomyces cerevisiae , Mei-41 of Drosophila and UVSB of Aspergillus nidulans [ 5 32 33 34 ] .
Indeed, p53 controls the low-level damage-dependent premeiotic checkpoint which facilitates DNA repair during spermatogenesis [ 25 ] . Gametogenesis is inherently error-prone [ 26 ] and subject to mutations [ 27 ] . Nevertheless, it is imperative to avoid genotoxic complications that could become integrated into the germline.
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