Words similar to gastritis
Example sentences for: gastritis
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The abbreviations used are: CSG, chronic superficial gastritis; CAG, chronic atrophic gastritis; DYS, dysplasia; GC, gastric adenocarcinoma; iNOS, inducible nitric oxide synthase; IM, intestinal metaplasia; VEGF, vascular endothelial growth factor.
Recently, both green tea and cat's claw have been reported to reduce the expression of inflammatory genes; responses that are linked to apoptosis and proliferation [ 23 24 25 26 27 ] . Indeed, cat's claw has been described as a potent inhibitor of the transcription factor NF-κB activation, preventing the expression of TNFα and inducible nitric oxide synthase [ 23 24 ] . These immune/inflammatory products are associated with gastritis and epithelial cell death [ 5 6 7 13 ] and hence cat's claw may have utility in limiting gut inflammation [ 23 ] . Indeed, this matches its ethnomedical use in South America where it is used to treat gastritis and other forms of chronic inflammation like arthritis [ 28 ] . Green tea, and its constituent polyphenols, has been associated with reduced expression of inflammatory genes and signal transduction processes leading to cell death [ 21 25 26 27 ] .
Indeed that is a concern that has been raised following the failure of prospective antioxidant trials in smokers to limit the incidence/progression of lung cancer [ 35 ] and the recent epidemiological analysis of gastric cancer incidence and green tea consumption [ 32 ] . However, other evidence has indicated that the antioxidants, vitamin E or N-acetylcysteine, enhanced the ability of the chemotherapeutic agent 5-fluorouracil to induce apoptosis in colon cancer cells [ 36 ] . These in vitro observations are supported by the Apc minanimal model [ 32 ] and sustained clinical trial in patients with H. pylori gastritis [ 30 ] suggesting that dietary antioxidants do not exacerbate precancerous states but may indeed promote regression.
The resultant nitrotyrosine is used as a marker of peroxynitrite or at least nitration reactions in gastritis [ 13 ] , inflammatory bowel disease [ 15 16 ] as well as general inflammation [ 17 ] . While we have demonstrated that peroxynitrite-induced apoptosis of macrophages and colon epithelial cells is reduced by ascorbic acid [ 18 ] , it is not known if other dietary antioxidants exert similar benefits or if they are present in epithelial cells from the upper gastrointestinal tract.
Although it has been shown that the CD4 +CD25 +regulatory T cells can suppress the development of autoimmunity, a recent report [ 27 ] demonstrated that depletion of the CD4 +CD25 +T cells is necessary but not sufficient for induction of autoimmune gastritis.
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