Words similar to fusion
Example sentences for: fusion
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The single archaeal fusion, the Arachaeoglobus fulgidus protein AF0227, belongs to one of these clusters and shows a strongly supported affinity with the ortholog from the hyperthermophilic bacterium Thermotoga maritima . (Figure 4a,4b).
All enteric bacteria and their nearest phylogenetic neighbors possess an aroQ•tyrA fusion.
The proto-oncogene TEL (Translocation, Ets, Leukemia) is a transcriptional repressor that contains a C-terminal Ets family DNA binding domain; a central domain that together with co-repressors recruit histone deacetylases [ 1 2 3 ] ; and an N-terminal SAM (sterile, alpha, motif) domain [ 4 5 6 ] , which we have recently shown forms a polymer [ 7 ] . Chromosomal translocations in a variety of leukemias result in fusion of the SAM domain of TEL to tyrosine kinase domains such as ABL, PDGFβ and JAK2 [ 8 9 10 11 12 13 14 ] or to the transcriptional activators AML1 and ARNT [ 15 16 17 ] . In the tyrosine kinase fusions, SAM domain polymerization leads to constitutive activation of the tyrosine kinase domains, which leads in turn to cell transformation [ 10 12 18 19 ] . Thus, compounds that block TEL-SAM polymerization could be effective in treating these leukemias.
The GAL4-β box fusion was prepared by synthesizing oligonucleotides corresponding to the β-box sequence with engineered EcoRI and SalI restriction sites.
This position of the E. coli and B. halodurans fusion components is unexpected and is in contrast to the placement of the orthologs from other gamma-proteobacteria and Gram-positive bacteria, as well as non-fused paralogs from the same species (AtoA/D and BH2258/2259, respectively) within the bacterial cluster.
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