Words similar to fsh
Example sentences for: fsh
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The promoters of several genes induced by FSH in Sertoli cells and granulosa cells, including c-Fos, transferrin, follicle stimulating hormone receptor, SF-1 genes and the RIIβ gene, contain functional E-box elements [ 21 22 23 24 ] . We found that several USF complexes containing full-length USF1 and USF2 as well as truncated versions, are formed at the consensus E-box/HLH-binding element in the RIIβ promoter in Sertoli cell nuclear extracts.
In vitro experiments with rat GCs have demonstrated that BMP-4 and -7 inhibit and stimulate FSH-induced progesterone and estradiol production, respectively [ 4 ] . In related studies BMP-6 and BMP-15 were found to block FSH action through inhibiting FSH-dependent adenylate cyclase activity and FSH receptor expression, respectively [ 11 12 ] . The importance of these findings is underscored by the fact that FSH action is obligatory for normal folliculogenesis and female fertility.
Referring physicians made the diagnosis of premature ovarian failure based on the following criteria: development of at least 4 months of amenorrhea before age 40 associated with two serum FSH levels above 40 IU/L (drawn at least 1 month apart).
Because BMP-6 can prevent FSH action [ 12 ] , the rapid loss of BMP-6 expression may be required for FSH to exert its crucial functions during DF-development.
Treatment with 4-AP (2 mM) decreased progesterone accumulation in the media of serum-supplemented GC cultures at 24 h and 48 h post-treatment, in the presence and absence of FSH (Figure 1).
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