Words similar to fsgs
Example sentences for: fsgs
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Importantly, biopsy samples from cases of FSGS that were matched for degree of proteinuria, renal function, and hypertension were characterized by TED, IF, and increased tubular epithelial apoptosis; however, proximal tubular CD36 expression was similar to that in normal human control kidney.
All patients with FSGS were from patients with creatinine levels of 1.7 to 4.9 mg/dl (151 to 435 μM/l), heavy proteinuria (3+ by dipstick), and hypertension.
Semi-quantitative analysis of the distribution and intensity of CD36-positive PTECs (CD36 PTEC score), which was performed by two independent pathologists in a blinded manner, demonstrated that mean CD36 PTEC scores were not different between FSGS kidneys and normal human kidneys, but were significantly increased in DNP kidneys (Figure 1K).
The diagnosis of FSGS was made on Periodic acid–Schiff staining in the absence of immunodeposits on electron microscopy.
Together, these findings indicate that CD36 expression in PTECs is associated with apoptotic events of proximal tubular cells and TED specifically in human DNP, but not in FSGS with matched functional and clinical abnormalities.