Words similar to frizzled-

Example sentences for: frizzled-

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When co-expressed with human frizzled-5, Wnt-5a can induce a secondary axis in Xenopus [ 10 ] . In other assays, however, Wnt-5a along with rat frizzled 2 (Rfz-2) increases intracellular Ca 2+levels and activates PKC and CamKII [ 4 5 6 ] . The activation of Wnt/Ca 2+signaling by Wnt-5a and Rfz-2 seems to be antagonistic to the canonical Wnt signaling pathway.
Wnt signaling is known to play a critical role in the development of the brain, and the midbrain and cerebellum do not form in animals lacking Wnt-1 [ 23 ] . Furthermore, targeted disruption of the frizzled-4 gene results in cerebellar abnormalities in mice [ 24 ] . Transgene expression from the PrP promoter is extremely low during embryonic development, with high-level postnatal expression largely restricted to neurons and glia of the CNS [ 25 ] . Transgenic mice expressing either wild-type or mutant β-catenin were generated so that a range of pathway activation could be examined.