Words similar to frizzled
Example sentences for: frizzled
How can you use “frizzled” in a sentence? Here are some example sentences to help you improve your vocabulary:
Vertebrate Wnts signal through frizzled receptors that in some experimental contexts (e.g.
Previously identified genes regulated by Wnt signaling in this list include fibronectin [ 17 ] , IL-6 [ 18 ] , BMP-4 [ 19 ] , groucho related protein [ 20 ] , and Krox-20 [ 21 22 ] . Since Wnt-5a may couple to more than one frizzled receptor, different Wnt signaling pathways may be activated by Wnt-5a depending on the endogenous expression of various frizzled receptors [ 6 10 ] . Thus, it is possible that the gene expression pattern we identified may be due to the activation of both canonical and noncanonical Wnt signaling pathways.
Zhao and colleagues [ 52] identified frizzled (denoted FZD2) as the human homologue of the Drosophila polarity-determining gene.
The assay makes use of Drosophila S2 cells in which two of the four fly Frizzled proteins are undetectable by a sensitive PCR assay.
Moreover, Frizzled receptors, Versican and other proteoglycans which contribute to Wnt protein activity are also controlled by Wnt signaling, as previously described in Drosophila [ 28 29 ] . At the level of transcriptional regulation, we found up-regulation of CBP/P300, which partners with β-catenin [ 30 31 ] but also TLE/Groucho, which is an inhibitor of TCF function [ 32 ] . These responses suggest a rich system of homeostasis and feedback control mechanisms, but they complicate the interpretation of experimental studies of Wnt signal transduction in which the time course of induction cannot be controlled easily.
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