Words similar to frizzled
Example sentences for: frizzled
How can you use “frizzled” in a sentence? Here are some example sentences to help you improve your vocabulary:
Moreover, Frizzled receptors, Versican and other proteoglycans which contribute to Wnt protein activity are also controlled by Wnt signaling, as previously described in Drosophila [ 28 29 ] . At the level of transcriptional regulation, we found up-regulation of CBP/P300, which partners with β-catenin [ 30 31 ] but also TLE/Groucho, which is an inhibitor of TCF function [ 32 ] . These responses suggest a rich system of homeostasis and feedback control mechanisms, but they complicate the interpretation of experimental studies of Wnt signal transduction in which the time course of induction cannot be controlled easily.
Mis-regulation of Wnt signaling leads to the development of several human cancers, including colon carcinomas and melanoma [ 1 ] . Canonical Wnt signaling initiates in the binding of a Wnt ligand to its cell surface receptor, members of the frizzled gene family, along with the co-receptor LRP5/6 [ 2 3 ] , leading to changes in the activities of cytoplasmic effectors resulting in the stabilization of beta-catenin protein.
Previously identified genes regulated by Wnt signaling in this list include fibronectin [ 17 ] , IL-6 [ 18 ] , BMP-4 [ 19 ] , groucho related protein [ 20 ] , and Krox-20 [ 21 22 ] . Since Wnt-5a may couple to more than one frizzled receptor, different Wnt signaling pathways may be activated by Wnt-5a depending on the endogenous expression of various frizzled receptors [ 6 10 ] . Thus, it is possible that the gene expression pattern we identified may be due to the activation of both canonical and noncanonical Wnt signaling pathways.
This developmentally important pathway contains several proteins, including APC, Frizzled, Axin and GSK3, which act in concert to promote the proteosomal degradation of β-catenin [ 13 14 ] . When APC is rendered inactive by mutation, β-catenin levels rise and the protein moves into the nucleus where it acts with Tcf/Lef cofactors to regulate transcription of c-myc , cyclin D and other oncogenes [ 15 ] .
When co-expressed with human frizzled-5, Wnt-5a can induce a secondary axis in Xenopus [ 10 ] . In other assays, however, Wnt-5a along with rat frizzled 2 (Rfz-2) increases intracellular Ca 2+levels and activates PKC and CamKII [ 4 5 6 ] . The activation of Wnt/Ca 2+signaling by Wnt-5a and Rfz-2 seems to be antagonistic to the canonical Wnt signaling pathway.
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