Words similar to frizzled
Example sentences for: frizzled
How can you use “frizzled” in a sentence? Here are some example sentences to help you improve your vocabulary:
, without co-expressing LRP5/6) preferentially activate the Wnt/beta-catenin or Wnt/Ca 2+pathways [ 5 ] . Interestingly, Wnt-5a may couple to either pathway depending on which frizzled receptor is present.
Wnt signal transduction proceeds through a complex series of protein interactions, initiated by binding of the Wnt protein to cell surface receptors (Frizzled and LRP [ 3 4 5 ] ) which generates a signal to downstream components.
This effect requires the aminoterminus of DFz2, implying a requirement for binding Wg to the Fz CRD, but not the carboxyterminus, suggesting that the signal may be, in part, transmitted through an interaction of Wg-Frizzled complex with another protein.
This developmentally important pathway contains several proteins, including APC, Frizzled, Axin and GSK3, which act in concert to promote the proteosomal degradation of β-catenin [ 13 14 ] . When APC is rendered inactive by mutation, β-catenin levels rise and the protein moves into the nucleus where it acts with Tcf/Lef cofactors to regulate transcription of c-myc , cyclin D and other oncogenes [ 15 ] .
The basis for the development of this planar or tissue polarity has principally been studied in Drosophila [ 1 2 3 4 ] where it is under the control of the frizzled ( fz ) pathway [ 5 ] . Many Drosophila epidermal cells produce cuticular hairs that are outgrowths from the apical surface of pupal epidermal cells.
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