Words similar to frizzled
Example sentences for: frizzled
How can you use “frizzled” in a sentence? Here are some example sentences to help you improve your vocabulary:
The medium was specifically depleted of Wnt-3A by adding an excess of a fusion protein containing the cysteine-rich domain of the Frizzled2 receptor of Drosophila (which binds to Wnt-3A protein) and alkaline phosphatase.
Wnt signal transduction proceeds through a complex series of protein interactions, initiated by binding of the Wnt protein to cell surface receptors (Frizzled and LRP [ 3 4 5 ] ) which generates a signal to downstream components.
Moreover, Frizzled receptors, Versican and other proteoglycans which contribute to Wnt protein activity are also controlled by Wnt signaling, as previously described in Drosophila [ 28 29 ] . At the level of transcriptional regulation, we found up-regulation of CBP/P300, which partners with β-catenin [ 30 31 ] but also TLE/Groucho, which is an inhibitor of TCF function [ 32 ] . These responses suggest a rich system of homeostasis and feedback control mechanisms, but they complicate the interpretation of experimental studies of Wnt signal transduction in which the time course of induction cannot be controlled easily.
When co-expressed with human frizzled-5, Wnt-5a can induce a secondary axis in Xenopus [ 10 ] . In other assays, however, Wnt-5a along with rat frizzled 2 (Rfz-2) increases intracellular Ca 2+levels and activates PKC and CamKII [ 4 5 6 ] . The activation of Wnt/Ca 2+signaling by Wnt-5a and Rfz-2 seems to be antagonistic to the canonical Wnt signaling pathway.
Previously identified genes regulated by Wnt signaling in this list include fibronectin [ 17 ] , IL-6 [ 18 ] , BMP-4 [ 19 ] , groucho related protein [ 20 ] , and Krox-20 [ 21 22 ] . Since Wnt-5a may couple to more than one frizzled receptor, different Wnt signaling pathways may be activated by Wnt-5a depending on the endogenous expression of various frizzled receptors [ 6 10 ] . Thus, it is possible that the gene expression pattern we identified may be due to the activation of both canonical and noncanonical Wnt signaling pathways.
Loading...