Words similar to fpm

Example sentences for: fpm

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Lieber and colleague observed that the "FPM" was reduced when ethanol was infused intraduodenally compared to the standard oral administration and concluded that the difference must have resulted from gastric mucosa metabolism [ 6 7 ] . This decreased FPM for the intradudenal dose is probably a result of the much more rapid time course of absorption when the ethanol is administered directly into the duodenum.
The error in both these approximations to FPM results primarily from the fact that the systemic appearance of the oral ethanol taken with a meal is slow compared to the 20 minute constant infusion that was used to obtain the IV AUC.
The classical procedure of determining FPM from the AUC (eq.
The difficulty in defining the FPM of ethanol has created a controversy over the question of the magnitude of ethanol metabolism that occurs in the stomach before reaching the liver [ 1 ] . It has been observed that the "FPM" is significantly reduced when ethanol is infused intraduodenally compared to the standard oral administration and this difference has been interpreted as representing gastric mucosal metabolism [ 6 7 8 ] . Clearly, if there are errors in the measurement of FPM then this estimate of gastric metabolism may be spurious.
Clearly, at this time, the rate of drug metabolism for an oral input must be identical to that for an IV input so that FPM must be zero, even though a large fraction of the absorbed drug may be metabolized in its first pass through the liver.