Words similar to fpm
Example sentences for: fpm
How can you use “fpm” in a sentence? Here are some example sentences to help you improve your vocabulary:
For the non-linear case, the intuitive idea that FPM is equal to the fraction of the absorbed drug that is metabolized in its first pass through the liver is no longer valid [ 2 ] . Consider the case where GI absorption is occurring at a time when the systemic drug concentration is so high that the liver metabolism is completely saturated and the metabolic rate is constant, independent of concentration.
7Bthat the PA (diamonds) is nearly identical to the GI absorption (squares) so that FPM is close to zero for the fasting subjects.
. As will be shown below, the actual FPM is much less than this.
15 gm/Kg) taken with a meal, the AUC estimate of fractional FPM of 73% was about twice the value (38%) obtained using PKQuest.
The error in both these approximations to FPM results primarily from the fact that the systemic appearance of the oral ethanol taken with a meal is slow compared to the 20 minute constant infusion that was used to obtain the IV AUC.
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