Example sentences for: follistatin

How can you use “follistatin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • For example, follistatin binds both activin and BMP-7 avidly but competes weakly or not at all with the type I receptor for BMP-4 binding [ 25 45 ] , whereas noggin binds to BMPs -2 and -4 with greater affinity than BMP-7 [ 46 ] . Whether BMP-5 function can be antagonized by noggin or follistatin has not been previously reported, but our results suggest that simultaneous addition of either antagonist with BMP-5 significantly inhibits the dendrite-promoting activity of BMP-5 in a concentration-dependent manner.

  • To address the former question, we tested the ability of follistatin and noggin to block the dendrite-promoting activity of BMP-5.

  • The chimeric protein containing BMPR-IA was chosen because it has been previously reported that this is the predominant BMP receptor type expressed in embryonic and postnatal superior cervical ganglia (SCG) [ 29 ] . As indicated in Figure 5, follistatin and noggin significantly inhibit the dendrite promoting activity of BMP-5 in a concentration-dependent manner.

  • These data suggest that Follistatin is activated directly through the Wnt signal transduction pathway and not by another pathway.

  • Because the kinetics of Follistatin activation by Wnt are similar to that of the other target genes (Figure 2A), we suggest that there are no "earlier" targets, i.e. all identified targets are direct.


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