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Example sentences for: fnas
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Selection of patients, treatment, and sampling of PBMC and FNAs
Because there are practical limits on the number of FNAs that can be carried out in the same lesion without causing excessive disturbance of its structure, we sampled lesions 3 hours after one dose (first four samples in the array) and four doses (remaining six samples) of IL-2.
This was done to evaluate whether FNAs obtained sequentially after one or four doses of IL-2 from identical or different lesions would cluster according to time of sampling or tissue of origin.
Genes were ranked according to their median ratio of expression among all FNA samples (FNAs obtained after one or four doses were pooled together to identify genes associated with IL-2 administration independent of dose number).
The genes whose expression was consistently altered in PBMC following IL-2 administration were analyzed in a set of FNAs obtained from the same patients plus an additional group of patients (Figure 4).