Words similar to fluoxetine
Example sentences for: fluoxetine
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For example, chronic treatment with fluoxetine decreases the release of AVP from rat hypothalamic organ cultures [ 36 ] . This finding is particularly noteworthy since alterations in AVP levels in the cerebrospinal fluid have been correlated with occurrences of OCD [ 15 16 ] . The occurrence of OCD has also been correlated with increased levels of oxytocin, a neuropeptide closely related to AVP [ 37 ] . In golden hamsters, the elevation of serotonin in the anterior hypothalamus following fluoxetine treatment can inhibit the activity of the AVP system related to aggressive behavior [ 10 11 ] . The ability of microinjected AVP in the anterior hypothalamus to enhance aggressive behavior in golden hamsters is blocked by fluoxetine treatment and serotonin 5HT 1A receptor agonists [ 10 ] . The present data include AVP-stimulated flank marking in the list of behaviors suppressed by fluoxetine treatment.
As noted earlier, fluoxetine is a selective serotonin re-uptake inhibitor while clomipramine is a non-selective re-uptake inhibitor of serotonin, and to some extent norepinephrine.
In canine acral lick dermatitis, the excessive licking of the paws and flanks was significantly reduced by fluoxetine and clomipramine two and three weeks into treatment, respectively [ 25 ] . However, the scale of the reduction was more pronounced over a five-week period of treatment [ 25 ] . Perhaps flank gland grooming would have been significantly altered in these studies if drug treatment had been extended for several more weeks.
Although the effects of fluoxetine and clomipramine on flank marking were statistically significant in the drug comparison studies (Fig 1), the effects were limited to a 30-40% reduction.
Animals were divided into four treatment groups: vehicle control (Veh, 75% Tris-buffer saline, pH 7.4, and 25% dimethyl sulfoxide; n=9), clomipramine hydrochloride (Clom, 2 mg/day; n=8), desipramine hydrochloride (Des, 2 mg/day; n=9) or fluoxetine hydrochloride (Fluox, 2 mg/day, n=8).
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