Words similar to fluoxetine
Example sentences for: fluoxetine
How can you use “fluoxetine” in a sentence? Here are some example sentences to help you improve your vocabulary:
However, NDA reviews for many other drug–indication combinations have not been posted: the Prozac Weekly formulation of fluoxetine, clozapine for suicidal behavior in patients with schizophrenia or schizoaffective disorder, and quetiapine for mania, among others.
The present data show that AVP-induced flank marking is selectively inhibited by chronic treatment with serotonin re-uptake inhibitors such as fluoxetine or clomipramine, instead of noradrenergic re-uptake inhibitors such as desipramine.
Clomipramine is a non-selective re-uptake inhibitor of serotonin, and to some extent norepinephrine [ 21 ] and fluoxetine is a selective serotonin re-uptake inhibitor [ 22 ] . Both of these drugs have proven to be effective in different animals models of OCD [ 23 ] . As an additional control, hamsters were also treated with desipramine, a noradrenergic re-uptake inhibitor [ 24 ] that has been found ineffective in inhibiting OCD in preclinical [ 25 ] and clinical studies [ 26 27 ] .
While bouts of grooming are coincident with flank marking, the selective inhibition of flank marking and not grooming by clomipramine and fluoxetine suggest the two behaviors employ different neuronal networks and neurochemical signals for their control.
For example, chronic treatment with fluoxetine decreases the release of AVP from rat hypothalamic organ cultures [ 36 ] . This finding is particularly noteworthy since alterations in AVP levels in the cerebrospinal fluid have been correlated with occurrences of OCD [ 15 16 ] . The occurrence of OCD has also been correlated with increased levels of oxytocin, a neuropeptide closely related to AVP [ 37 ] . In golden hamsters, the elevation of serotonin in the anterior hypothalamus following fluoxetine treatment can inhibit the activity of the AVP system related to aggressive behavior [ 10 11 ] . The ability of microinjected AVP in the anterior hypothalamus to enhance aggressive behavior in golden hamsters is blocked by fluoxetine treatment and serotonin 5HT 1A receptor agonists [ 10 ] . The present data include AVP-stimulated flank marking in the list of behaviors suppressed by fluoxetine treatment.
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