Words similar to fluorouracil
Example sentences for: fluorouracil
How can you use “fluorouracil” in a sentence? Here are some example sentences to help you improve your vocabulary:
Indeed that is a concern that has been raised following the failure of prospective antioxidant trials in smokers to limit the incidence/progression of lung cancer [ 35 ] and the recent epidemiological analysis of gastric cancer incidence and green tea consumption [ 32 ] . However, other evidence has indicated that the antioxidants, vitamin E or N-acetylcysteine, enhanced the ability of the chemotherapeutic agent 5-fluorouracil to induce apoptosis in colon cancer cells [ 36 ] . These in vitro observations are supported by the Apc minanimal model [ 32 ] and sustained clinical trial in patients with H. pylori gastritis [ 30 ] suggesting that dietary antioxidants do not exacerbate precancerous states but may indeed promote regression.
Consistent with these pre-clinical studies, the design of this phase II trial involved a fluorouracil infusion that was initiated one hour into the 2 hour high dose infusion of LV and 36 hours after the initial methotrexate dosing.
5-FU: 5-fluorouracil
The results of cell culture and animal studies have shown that omega 3 polyunsaturated fatty acids (n-3 PUFAs) selectively killed cancer cells in vitro [ 1 ] . Furthermore, n-3 PUFAs incorporated into animal diets have reduced tumor growth rates in vivo [ 2 3 4 ] . The prevailing hypothesis for the reduction in tumor cell growth, in vitro or in vivo , by supplementing the diet with high levels of n-3 PUFAs has been that the incorporation of n-3 PUFAs into cell membranes of the tumor cells increased the susceptibility of the cells for lipid peroxidation and that the products of lipid peroxidation subsequently accumulated to cytostatic or cytotoxic levels [ 2 5 6 7 ] . It has also been reported that supplementing the diet of cancer xenograft bearing mice with n-3 PUFAs could increase the efficacy of edelfosine [ 8 ] , doxorubicin [ 9 ] , mitomycin [ 10 ] , cyclophosphomide and 5-fluorouracil [ 11 ] or irinotecan [ 12 ] against the tumor.
Although a number of recently introduced chemotherapeutic agents have demonstrated significant anti-tumor activity in advanced colorectal cancer, [ 1 2 3 4 5 6 7 8 9 ] standard therapy for patients with metastatic disease remains 5-fluorouracil (5-FU) - based chemotherapy.
Loading...