Words similar to fbn
Example sentences for: fbn
How can you use “fbn” in a sentence? Here are some example sentences to help you improve your vocabulary:
Of those, 1166 (5%) are gross deletions http://archive.uwcm.ac.uk/uwcm/mg/hgmd0.html [ 27 ] suggesting that more FBN1 genomic deletions await recognition.
Thus, we have only detected two genomic deletions out of 105 unique disease-causing FBN1 mutations identified in our laboratory.
Both mutations lead to the synthesis of mutant FBN1 proteins that interfere with microfibril assembly, resulting in significantly reduced extracellular matrix microfibrils.
The MFS phenotype is the result of mutations in FBN1, a large gene composed of 65 exons encoding the 350 kD fibrillin-1 protein that is the major constituent of microfibrils in the extracellular matrix (reviewed in [ 3 ] ). To date, 201 unique FBN1 mutations have been identified, including 70 (34.
Therefore, we suspected that these normal amplification products were derived from the normal FBN1 alleles, and that the mutant alleles were not amplified by this approach because they carry gross genomic deletions.