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Example sentences for: fba

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These case studies were chosen to further investigate the metabolic genotype-phenotype relation in silico and to demonstrate the use of FBA to interpret and analyze cellular metabolism.
However, FBA does have predictive capabilities when a physiologically meaningful objective function can be defined, and the E. coli FBA results, with maximal growth rate as the objective function, have been shown to be consistent with experimental data under nutritionally rich conditions [ 40].
It should be mentioned that FBA does not directly consider regulation, or the regulatory constraints on the metabolic network, but rather FBA assumes that the regulation is such that metabolic behavior is optimal.
The fba -, pfkAB -, and tpiA - in silico deletion strains had a limited capability to synthesize glyceraldehyde 3-phosphate, 3-phosphoglycerate, phosphoenolpyruvate, pyruvate, acetyl-CoA, α-ketoglutarate, succinyl-CoA, oxaloacetate, and high-energy phosphate bonds in all phases, and were completely unable to synthesize many of the biosynthetic precursors in phases 46 (Table 1) ( tpi - in silico strain discussed below).
Acetate production can be interpreted using FBA [ 36, 37], and we have used a phase plane analysis to quantitatively analyze the conditions for which acetate excretion optimally occurs.