Words similar to fasn
Example sentences for: fasn
How can you use “fasn” in a sentence? Here are some example sentences to help you improve your vocabulary:
These same conclusions regarding energy expenditure were reached in experiments assessing enzymatic activities, and transcriptional changes in rat liver using Northern blots, where fish oil feeding: increased palmitoyl CoA mitochondrial and peroxisomal oxidation rate; increased Cpt1, Cpt2, Δ 3, Δ 2-enoyl CoA isomerase, and Ech1 expression and activity; and decreased expression and activity of FA synthase, malic enzyme, glucose 6-phosphate dehydrogenase, and pyruvate kinase, compared to palm and/or safflower oil feeding [ 93 ] . Likewise, in rat white retroperitoneal adipose tissue, fish oil feeding also decreased Fasn expression [ 94 ] . Intriguingly, the hormone leptin, which also acts through SREBP-1 and PPARα, affected many transcripts similarly to LC-PUFA ( e.g. , leptin decreased Gpam and Apoa4 transcripts; and up regulated Ech1, mitochondrial Hmgcs2, and Cyp4a14 transcripts [ 95 ] .
The NF-Y transcription factor adds further complexity to transcriptional regulation since it can interact and modulate the expression of SREBP-1c target genes containing Y-box motifs, such as those found in Fasn [ 37 ] . Mutating the NF-Y binding site in Fasn relieved LC-PUFA-induced Fasn down regulation [ 39 ] . Nfyb was differentially expressed after dietary LC-PUFA addition (1.
It is intriguing that, in general, both Acly and Fasn were more strongly down regulated with the combination diet than the individual LC-PUFA.
It has previously been shown that the Acly gene in human cultured hepatic cells has a regulatory region from -61 to -49 in the 5' flanking region similar to that of Fasn, which is responsive to insulin and LC-PUFA [ 44 ] . In the present experiment, there was coordinated down regulation of both Acly (between -1.
In the cytoplasm, FA synthesis is controlled via Acly, acetyl CoA carboxylase (ACC), and Fasn.
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