Words similar to fak

Example sentences for: fak

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TGFβ 1 bound to α V β 6 -integrin in these cells as well, and this interaction resulted both in an immobilization of p130Cas and SOS1/2 and in tyrosine phosphorylation of cytoskeleton-associated proteins such as p125FAK.
For a number of GPCRs, including the lysophosphatidic acid (LPAR) [ 7 ] , β-adrenergic 2 (β 2 -AR) [ 8 ] and μ- and δ-OR receptors [ 9 ] , the activation of a non-receptor tyrosine kinase of the Src or focal adhesion kinase (FAK) [ 10 ] families are involved.
KHK generated stable cell lines carrying the chimeras, and characterized these lines in soft agar transformation assays, activation of JNK, tyrosine phosphorylation of FAK, endogenous Cas and association of C3G with endogenous crk.
One of the established in vivo substrates of PTEN, FAK, is known to play a major role in growth-regulatory signal transduction initiated by cell surface integrin receptors [ 48 49 ] . As we observe a correlation between increased PTEN activity and decreased levels of FAK phosphorylation (compare Figure 4Band Figure 5), it is likely that the dephosphorylation of FAK in response to the disruption of cell-matrix interactions is accomplished by increased PTEN activity.
As shown in Figure 5, the detachment of MDAH cells from their matrix resulted in decreased tyrosine-specific phosphorylation of FAK.