Words similar to fak
Example sentences for: fak
How can you use “fak” in a sentence? Here are some example sentences to help you improve your vocabulary:
Indeed, TGFβ 1 antibodies, cytochalasin D and BAPTA-AM [ 66 ] abolished the association on the cytoskeleton connected with integrin α V β 6 and activation of p125 FAK.
Focal adhesion kinase (FAK) is a known substrate for PTEN and has been shown to be dephosphorylated by this phosphatase in vitro and in vivo [ 20 21 34 ] . We therefore determined whether the increased PTEN phosphatase activity would correlate with decreased phosphorylation of FAK in our cells.
Figure 7bdemonstrates that there was no difference in tyrosine phosphorylation or association with tyrosine phosphorylated proteins of either FAK or endogenous Cas upon stable expression of the tyrosine phosphorylated Cas SD chimera.
This protein acts as inhibitor of cyclin-dependent kinases (the "cell cycle engine" [ 50 ] ), and its elevated expression has been consistently demonstrated in different cell types after the disruption of cell-matrix interactions (compare Figure 1and [ 31 32 51 52 ] ). Furthermore, p27 Kip1is an established target of PTEN signaling, i.e., its activity has been found increased after the forced expression of exogenous PTEN [ 53 54 55 56 ] . In combination with the data presented in this manuscript, it therefore appears that PTEN contributes to anchorage-dependent growth control by a two-fold approach: the dephosphorylation of the signaling molecule FAK in combination with the stimulation of the cell cycle inhibitor p27 Kip1.
KHK generated stable cell lines carrying the chimeras, and characterized these lines in soft agar transformation assays, activation of JNK, tyrosine phosphorylation of FAK, endogenous Cas and association of C3G with endogenous crk.
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