Words similar to fak

Example sentences for: fak

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Figure 7bdemonstrates that there was no difference in tyrosine phosphorylation or association with tyrosine phosphorylated proteins of either FAK or endogenous Cas upon stable expression of the tyrosine phosphorylated Cas SD chimera.
Beatrice Knudsen, Weill Medical College of Cornell University, NY, NY); anti-FAK and anti-Cas (Transduction Laboratories, Lexington, KY).
This protein acts as inhibitor of cyclin-dependent kinases (the "cell cycle engine" [ 50 ] ), and its elevated expression has been consistently demonstrated in different cell types after the disruption of cell-matrix interactions (compare Figure 1and [ 31 32 51 52 ] ). Furthermore, p27 Kip1is an established target of PTEN signaling, i.e., its activity has been found increased after the forced expression of exogenous PTEN [ 53 54 55 56 ] . In combination with the data presented in this manuscript, it therefore appears that PTEN contributes to anchorage-dependent growth control by a two-fold approach: the dephosphorylation of the signaling molecule FAK in combination with the stimulation of the cell cycle inhibitor p27 Kip1.
The underlying processes involve the stimulation of expression of p27 Kip1and the dephosphorylation of FAK.
In parallel, phosphorylation of FAK, a known target of PTEN, is greatly reduced.