Example sentences for: exonuclease

How can you use “exonuclease” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • We have chosen to illustrate this approach using the multifunctional family of DNA repair proteins, the apurinic/apyrimidinic endonucleases (APEs), which have a clearly defined bacterial ancestor, E. coli exonuclease III (ExoIII), and are distantly related to several enzymes with varying substrate specificity.

  • The exact nucleotide positions where telomere repeats are added have been examined in several ciliates (reviewed by [ 23 53 ] ). Cloned chromosome ends from 81 MAC family indicated heterogeneity of TAS placement, which we attributed to exonuclease erosion of the broken ends prior to telomerase action [ 27 ] . Analogous multi-TAS regions have been described in Tetrahymena ( [ 49 ] ; E. Hamilton and E. Orias, pers.

  • Of the four protein areas that bind to the DNA 3' of the abasic site, mutating F266 (molego 10) or W280 (middle of molego 11) decreases APE activity [ 33 ] . The F266 mutation is particularly interesting, as the mutants at this position had reduced substrate specificity and enhanced 3'-exonuclease activity.

  • APEs also have RNase H, 3'-exonuclease, and 3'-phosphodiester activities that are particularly high in the bacterial members of the family [ 26 13 ] .

  • We purified the genomic amplicons with exonuclease and shrimp alkaline phosphatase (United States Biochemical) and sequenced them directly with primers E41S, E43S, E44AS and E47AS [ 15 ] .


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