Words similar to exocytosis
Example sentences for: exocytosis
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In primates SPAM1 has been shown to play a role in three functions during fertilization: (1) hyaluronidase enzyme activity necessary for penetrating the cumulus [ 3 ] and for which it is best known [ 4 ] , (2) zona pellucida binding [ 3 ] , and (3) Ca 2+signaling-associated acrosomal exocytosis [ 5 6 7 ] .
Mint2 functions as a neuronal adaptor protein that binds to the Munc18-1 protein, which is essential for synaptic vesicle exocytosis [ 23 ] . Biederer and Südhof have shown that a multiprotein complex containing Mint1 (APBA1) binds to the cytoplasmic tail of neurexins, which play a critical role in synaptic vesicle exocytosis.
Thus the Mint proteins serve to anchor Munc-18 to the neurexins and thereby facilitate exocytosis.
Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the gene encoding the CFTR chloride channel [ 1 ] . CFTR is known to possess multiple cellular functions beyond its role as an apical membrane chloride channel [ 2 ] . For example, regulation of other ion channels, such as the epithelial sodium channel and the outwardly rectified chloride channel, are well-described functions of CFTR [ 3 4 ] . Numerous other functions, such as regulation of intracellular vesicular pH, regulation of membrane recycling, and regulation of mucin exocytosis are less firmly established.
Phorbol esters are often used as activators of protein kinase C (PKC) to investigate the role of the kinase in cellular functions [ 1 ] . Pancreatic β-cells possess α, β1, δ and ε PKC isotypes [ 2 ] , and activation of PKC is known to synergize with glucose stimulation in insulin secretion [ 3 4 5 ] . PKC, via protein phosphorylation seems to facilitate exocytosis of insulin granules [ 6 7 8 ] . In glucose-stimulated insulin secretion, ATP-sensitive K +channels (K ATP (SUR1, Kir6.
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