Example sentences for: excitability

How can you use “excitability” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Metabotropic glutamate receptors (mGluRs) are a family of class 3 G protein-coupled receptors with important functions in the regulation of synaptic transmission, plasticity, neuronal excitability, and the regulation sensory transduction [ 1 2 3 4 5 ] . The eight mGluRs (mGluR1-8) and their splice variants have been divided into three groups (I-III) based on sequence homology, pharmacology and G protein coupling profiles [ 3 6 7 ] . Group II (mGluR2 and 3) and III (mGluR4, and 6 through 8) couple negatively to adenylate cyclase through activation of the G i/o family of G proteins [ 8 ] . Group I mGluRs (mGluR1 and 5) couple to multiple G proteins in native and heterologous systems, and have been observed to couple to G q/11 , G i/o and/or G s [ 9 10 11 12 13 14 15 ] . mGluRs appear to be important mediators of synaptic transmission in the brain.

  • The knockout mouse is also susceptible to epileptic-like seizures - suggesting that the 5-HT 2C receptor has a role in tonic inhibition of neuronal excitability.

  • Sensory neurons react to peripheral nerve injury by increasing their excitability, changing their constitutive synaptic transmitter profile and even their synaptic contacts in the spinal cord.

  • The assumption that stuttering might be a form of dystonia—involuntary muscle contractions produced by the CNS—specific to language production (Kiziltan and Akalin 1996) was not supported by a study on motor cortex excitability (Sommer et al.

  • Small increases in pCO 2 (5-20% above normal) cause decreased cerebral excitability and an increased electroshock seizure threshold.


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