Words similar to esx
Example sentences for: esx
How can you use “esx” in a sentence? Here are some example sentences to help you improve your vocabulary:
ets-1, ets-2 and ese-1/esx . Smad7 was of particular interest as it belongs to the inhibitory Smads, which can counteract TGFβ-induced gene activation [ 23 ] . The response of the smad7 gene to TGFβ is unusually rapid [ 24 ] which is believed to stem from the peculiar nature of the Smad7 promoter that contains a "perfect" Smad binding site [ 25 ] . Another inhibitory Smad protein is Smad6.
Furthermore, we show for the first time that, in breast cancer cells, the Ese-1/Esx mRNA is downregulated by TGFβ.
One way by which Smad7 can inhibit TGFβ-dependent gene expression is by blocking phosphorylation, and, hence, nuclear import of Smad3 and Smad2 [ 23 ] . More recent data showing that Smad7 is able to interact with histone deacetylases suggest an additional role for Smad7 as a transcriptional co-repressor [ 50 ] . Thus, Smad7 might interfere directly with Ese-1/Esx gene transcription.
However, TGFβ downregulated Ese-1/Esx mRNA levels faster than it upregulated Smad7 expression excluding the possibility that Smad7 mediates the TGFβ effect on Ese-1/Esx, at least at the initial phase.
The negative TGFβ effect on Ese-1/Esx expression could not be inhibited by SB-203580.
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