Words similar to estrogen-sensitive
Example sentences for: estrogen-sensitive
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Some studies also indicate that estrogen receptors reside on the plasma membrane and modulate cellular activity without directly associating with DNA [ 16 ] . Human ERβ is encoded by 477 amino acids (~52 kDa) and has substantial homology to ERα (66 kDa) [ 17 18 ] . Although both estrogen receptors (ERs) can be expressed in various estrogen-sensitive tissues and cells, evidence is accumulating that their expression varies during cellular proliferation and differentiation [ 19 ] . It appears quite clear today that ERβ has biological roles that are distinct from those of ERα, and certain results indicate that ERβ can have effects opposite to those of the ERα [ 20 21 ] .
“One setting was an assay on an estrogen-sensitive cancer cell line.
As mentioned in the Introduction, recent studies of the functional significance of ERβ in βERKO mice show that ERα is sufficient for basic differentiation of estrogen-sensitive tissue.
Investigations of intermediate filaments (IF) in the nucleus have focused on lamins (see Goldman for a current review) [ 8 ] , but many reports of in situ nuclear localization of cytoplasmic IFs also exist, e.g., vimentin in association with nuclear DNA in cultured fibroblasts [ 9 10 ] , and an estrogen-sensitive cytokeratin association with nuclear DNA in human breast cancer cells [ 11 ] .
Nuclear ERα expression is characteristic of estrogen-sensitive cells, which might be stimulated by estrogens to proliferate as well as modulate differentiated functions.
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