Words similar to erβ
Example sentences for: erβ
How can you use “erβ” in a sentence? Here are some example sentences to help you improve your vocabulary:
The isolated β-box also acted as bait for a VP16-ERβ fusion protein in mammalian cells, and did so with similar efficiency to other known ERβ interacting peptides (Fig.
After washing in TBST, the ERβ protein was visualized with a chemiluminescent detection system (ECL; Amersham Pharmacia Biotech, Piscataway, NJ) as recommended by the manufacturer, and exposed on Kodak XAR film (Eastman Kodak, Rochester, NY).
ERα and ERβ (~52 kDa) immunoreactivity in various placental cell types is summarized in Table 2. From trophoblast cell types, the villous CT expressed ERα only, while ST and EVT showed ERβ.
While the ER isoforms have contrasting effects on AP-1 activity in the presence of estrogens, ERα truncations that lack the NTD and ERβ both enhance AP-1 activity in the presence of SERMs [ 30 31 ] . Mutational analysis of ERα action at AP-1 sites suggests these effects may be related to N-CoR binding [ 39 ] , and we have proposed that SERM action at AP-1 sites may therefore involve contacts with corepressors [ 31 51 ] . The fact that ERα and ERβ show completely different ligand preferences of interaction with N-CoR suggests that the target for SERM activation at AP-1 sites may not be N-CoR in both cases.
Therefore, these placental cell types appear to be responsive to estrogens via the nuclear ERβ hormone binding domain.