Words similar to ers
Example sentences for: ers
How can you use “ers” in a sentence? Here are some example sentences to help you improve your vocabulary:
However, CT cells merging with ST and young syncytial aggregates showed expression of both ERs.
ERα enhances AP-1 activity in response to estrogens, [ 28 29 ] but ERβ inhibits AP-1 activity in response to estrogens [ 29 30 31 ] . ERβ also completely suppresses ERα activity at the cyclin D1 promoter and even suppresses the activity of an ERα mutant that is selectively superactive at AP-1 sites and CREs [ 29 ] . Finally, ERβ shows a unique capacity to enhance AP-1 activity in response to selective estrogen receptor modulators (SERMs) such as raloxifene, tamoxifen and ICI 182,780/Faslodex (ICI) [ 30 31 32 ] . Together, these observations suggest that there are fundamental differences in the way that the ERs bind unspecified cofactors that modulate gene expression, and that some of these cofactors must play a role in differential ER activity at AP-1 sites.
The NR family contains two related ERs (ERα and ERβ) that conform to the typical three domain NR structure and share extensive sequence homology in the DBD and LBD region [ 20 21 ] . Analysis of the function of the individual ERs in mouse knockout models suggests that the major proliferative effects of estrogen are mediated by ERα and not by ERβ, which seems to play an inhibitory role in proliferation in some studies [ 22 23 ] . The ligand-binding properties of the ERs are different, with ERβ often exhibiting stronger binding to plant-derived phytoestrogens [ 24 ] . More importantly, the ERs exhibit isoform-specific effects on gene expression.
However, TSA also equalized the relative transcriptional activity of both ERs.
Labeled ERs were produced using coupled in vitro transcription-translation (TNT kit, Promega, Madison, Wisconsin).
Loading...