Example sentences for: ers

How can you use “ers” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In situ hybridization and immunolocalization of ERα and ERβ in a variety of reproductive tract tissues in males and females have shown that in most instances either ERα or ERβ is expressed in a particular cell type, although some cell types, e.g., Leydig cells, ovarian surface epithelium, and epithelial and stromal cells of the uterus and breast, may show expression of both ERs [ 39 40 41 ] . However, since only a proportion of cells were detected to express ERα or ERβ in a single color immunohistochemistry [ 42 ] , such an approach cannot demonstrate coexpression of the ERs in a particular cell, nor indicate eventual transition from one ER subtype to another during differentiation.

  • ERα enhances AP-1 activity in response to estrogens, [ 28 29 ] but ERβ inhibits AP-1 activity in response to estrogens [ 29 30 31 ] . ERβ also completely suppresses ERα activity at the cyclin D1 promoter and even suppresses the activity of an ERα mutant that is selectively superactive at AP-1 sites and CREs [ 29 ] . Finally, ERβ shows a unique capacity to enhance AP-1 activity in response to selective estrogen receptor modulators (SERMs) such as raloxifene, tamoxifen and ICI 182,780/Faslodex (ICI) [ 30 31 32 ] . Together, these observations suggest that there are fundamental differences in the way that the ERs bind unspecified cofactors that modulate gene expression, and that some of these cofactors must play a role in differential ER activity at AP-1 sites.

  • However, it has to be considered that ERs are certainly not the only proteins which are involved in decisions of estrogen-dependent cells to proliferate or differentiate.

  • However, CT cells merging with ST and young syncytial aggregates showed expression of both ERs.

  • The San Diego Chargers, the Oakland Raiders, and the San Francisco 49ers all have large and faithful followings.


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