Words similar to epithelial-mesenchymal
Example sentences for: epithelial-mesenchymal
How can you use “epithelial-mesenchymal” in a sentence? Here are some example sentences to help you improve your vocabulary:
Following a classic epithelial-mesenchymal interaction developmental program, the mouse neonatal submandibular salivary gland (SMG) is comprised of large and small ducts which terminate in lumen-containing, presumptive acini that express embryonic mucin [ 1 2 3 4 5 6 7 8 ] . Progressive prenatal morphogenesis begins as a solid outgrowth from the oral epithelium around E11.
Interestingly, jagged-1 is important for epithelial-mesenchymal cell interaction in development [ 50], and mutations in the jagged gene lead to Alagille syndrome, a congenital connective tissue disorder whose hallmarks include craniofacial and vertebral deformities [ 51].
Evidence has been accumulated that TGFβ promotes late-stage tumorigenesis by stimulating angiogenesis and invasive behaviour of tumor cells, enhancing immunosuppression and supporting epithelial-mesenchymal transition of cancer cells [ 4 ] . Furthermore, TGFβ is believed to be part of a vicious circle in bone metastases as it gets released from osteoclast-degraded bone substance and subsequently stimulates PTHrP gene expression in nearby metastatic cancer cells which in turn leads to an activation of osteoclastic bone resorption [ 11 ] . Therefore, it is of great interest to understand in more detail the molecular aspects of TGFβ-mediated gene expression in metastatic breast cancer cells and to explore ways to interfere with this tumorigenic signalling.
From this point of view, one should consider an involvement of epithelial-mesenchymal and mesenchymal-neural interactions as components of mesenchymal-epithelial network.
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