Words similar to epileptiform
Example sentences for: epileptiform
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reported that under epileptogenic condition (free Mg 2+in ACSF), γ band oscillations arise from GABAergic depolarizations and that this activity may lead to the generation of ictal discharges [ 18 ] . It has been reported that prolonged periods of γ oscillations are associated with temporal lobe seizures in in vivo rats [ 41 ] . Furthermore, human EEG studies with subdural recording electodes showed that a γ band oscillation could be recorded at the start of typical seizure activity [ 42 ] . In this respect, the hyperthermic γ oscillations may also play a critical role in generation of neuronal epileptiform activity.
The epileptiform discharges demonstrated a frequency of 80 Hz (Fig.
The specific GABA A receptor antagonist, bicuculline, blocks the γ oscillations [ 14 16 ] , an action that can be modeled by simulated neuronal networks [ 17 ] . The γ band oscillations appear to play an important role in generation of ictal epileptiform activity in hippocampal slices [ 18 ] . This study explores the role of γ oscillations in epileptiform activity in the hyperthermic rat hippocampal slice.
This concept has been strengthened by evidence from several in vitro models, in which pharmacological manipulations of gap junctional communication predictably affect the generation of seizures: blockers diminishing seizure, and enhancers increasing the seizures [ 4 ] . GJ channels can contribute to the prolongation of epileptiform discharges [ 5 ] .
In in vitro studies, carbenoxolone abolished the generation of full or partial ectopic spike generation, by 4-AP, in the CA 3 region of rat hippocampal slices [ 6 ] . Also carbenoxolone depresses spontaneous epileptiform activity in the CA 1 region of rat hippocampal slices [ 7 ] . Carbenoxolone appears to cross the blood brain barrier about one hour after an intraperitoneal injection in rats as there was the inhibition of 11-β-hydroxysteroid dehydrogenase in multiple brain regions [ 1 ] . It and/or its congener glycyrrehetinic acid may also enter the eyes of humans.
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