Words similar to epigenetic
Example sentences for: epigenetic
How can you use “epigenetic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Microsatellite instability (MSI) is hallmark of mismatch repair-deficient cancers, which has been observed in all cancers arising from Hereditary Non-polyposis Colorectal Cancer (HNPCC) syndrome, some sporadic colorectal and other cancers [ 38 ] . MSI is generally associated with germ-line mutations in one of two MMR genes, hMLH1 and hMSH2 . Epigenetic inactivation of promoter hypermethylation of APC and HIC1 also results in MSI phenotype in sporadic colorectal cancers [ 39 40 ] . Accumulating evidence supports the view that promoter methylation of mismatch repair genes may be related to MSI phenotype [ 41 42 ] . A number of previous studies have shown the existence of MSI phenotype in CC [ 43 44 ] . In the present study, we found that MSI-H occurs at an increased frequency in tumors with HIC1 and APC promoter hypermethylation.
The trans-silencers as well as their targets reside in single-copy, gene-rich regions that are only sparsely populated with repetitive or transposable elements, features that have been shown to mediate epigenetic activity in other cases [ 18 31 32 ] . Therefore trans-silencing of GFP-COP1 is probably not mediated by transgene flanking sequences [ 27 ] . In contrast, as with other genes cited above, trans-silencing ability is correlated with transgene locus structure, given that the C73 and C97 trans-silencers contain multiple T-DNAs while their targets, E82 and L91, are essentially dimeric and monomeric, respectively.
4. Cosuppression phenotypes can serve as sensitive indicators of epigenetic interactions between transgenes in Arabidopsis thaliana.
Paramutation has been studied extensively for four maize loci that encode transcriptional regulators of pigment biosynthesis [ 1 ] . Paramutation has also been investigated in the Arabidopsis PAI gene family, at the a1 and chalcone synthase (CHS) transgene loci in petunia, and in a number of other cases [ 2 3 4 ] . The Arabidopsis resistance gene BAL/CPR1 displays a related form of epigenetic instability [ 5 6 ] . Interactions resembling paramutation also occur among non-allelic transgene loci with DNA sequence homology.
Many of the most potent epigenetically active loci are endogenous rather than transgenic and, therefore, their early epigenetic history is not completely known.
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