Words similar to epigenetic

Example sentences for: epigenetic

How can you use “epigenetic” in a sentence? Here are some example sentences to help you improve your vocabulary:

MGMT gene encodes O(6)-methylguanine-DNA methyltransferase and this enzyme effectively removes DNA adducts formed by alkylating agents [ 33 ] . Epigenetic gene silencing of MGMT confers enhanced sensitivity to alkylating-based chemotherapy, and lack of methylation associates with failure to respond to chemotherapy [ 34 35 ] . On the contrary, all patients that had MGMT promoter methylation were dead within 21 months of initial diagnosis, which predicts a poor prognosis.
This knowledge of epigenetic changes in CC may have implications in our understanding of the role they play in CC development.
Distinct patterns of promoter methylation between SCC and AC, however, suggest that epigenetic pathways of tumor suppression may be different in these histologic subtypes.
The first comparison relates to the speed of epigenetic change.
Epigenetic mechanisms of gene silencing are increasingly being recognized to affect a number of molecular pathways in human cancer [ 12 ] . The extent and the nature of such epigenetic modifications in GCTs are currently poorly understood.